A combined “1-4-7” algorithm
| Selection Criteria . | Degenerate Bindersa . | % of Total Degenerate Binders . | χ2 (p) . |
|---|---|---|---|
| None | 73/384 | 100 | —b |
| P1-P6 | 72/259 | 99 | 13.0 (<0.005) |
| Combined algorithms (90% cutoff value) | 67/147 | 92 | 67.4 (<0.005) |
| Combined algorithms (75% cutoff value) | 59/100 | 81 | 103.9 (<0.005) |
| Selection Criteria . | Degenerate Bindersa . | % of Total Degenerate Binders . | χ2 (p) . |
|---|---|---|---|
| None | 73/384 | 100 | —b |
| P1-P6 | 72/259 | 99 | 13.0 (<0.005) |
| Combined algorithms (90% cutoff value) | 67/147 | 92 | 67.4 (<0.005) |
| Combined algorithms (75% cutoff value) | 59/100 | 81 | 103.9 (<0.005) |
Degenerate binders are defined as peptides binding at least two of the three DRB1*0101, -*0401, and -*0701 molecules with an IC50 of 1 μM or less.
Not applicable.