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Table II.

Serum IFN-γ levels after in vivo depletion of NK cell or both NK cells and NK1+ T cells in the Shwartzman reactiona

MicePretreatmentTreatmentSerum IFN-γ (pg/ml)
B6 None None None detected 
 None IL-12 7593.1 ± 392.9b 
 Anti-AGM1 Ab IL-12 5343.3 ± 113.7† 
 Anti-NK1 Ab IL-12 1273.1 ± 209.2 
β2m−/− None IL-12 2243.1 ± 206.4‡ 
MicePretreatmentTreatmentSerum IFN-γ (pg/ml)
B6 None None None detected 
 None IL-12 7593.1 ± 392.9b 
 Anti-AGM1 Ab IL-12 5343.3 ± 113.7† 
 Anti-NK1 Ab IL-12 1273.1 ± 209.2 
β2m−/− None IL-12 2243.1 ± 206.4‡ 
a

Prior to treatment with nothing or 0.5 μg IL-12 (i.p.), mice were pretreated with nothing, anti-AGM1 Ab (50 μg/injection), or anti-NK1 Ab (200 μg/injection). Sera were collected 24 h after the IL-12 injection, and the IFN-γ levels were assayed. The data represented are mean ± SD of five mice in each group.

b

p < 0.01 vs anti-AGM1 Ab/IL-12-treated mice; †p < 0.01 vs anti-NK1 Ab/IL-12-treated mice; ‡p < 0.01 vs IL-12-treated B6 mice.

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