American Association of Immunologists

Table III.

Light chain variable region genes encoding anti-Hib PS mAbs from infants^a

mAb	V_L	Total			FR			CDR				JL
mAb	V_L			NA	AA	NA	AA	NA	AA			NA	AA	R
Hib PS inhibitable mAbs
MM1.5	VκII A2	98.0	96.0	98.6	96.7	96.7	95.7	Jκ3	100.0	100.0	+
MM4.1	VκII A2	98.3	97.0	99.0	96.7	96.7	97.1	Jκ3	100.0	100.0	+
Noninhibitable mAbs
MAX1	VκI L1	100.0	100.0	100.0	100.0	100.0	100.0	Jκ3	100.0	100.0	−
MAX4.	VκII A2	97.7	96.0	98.6	97.1	96.7	90.0	Jκ4	90.0	81.8	−
MAX5	VκIII L6	100.0	100.0	100.0	100.0	100.0	100.0	Jκ1	97.4	100.0	−
MAX6	VλVII DPL18	100.0	100.0	100.0	100.0	100.0	100.0	Jλ1	100.0	100.0	−
MAX8	VλI DPL2	98.0	98.0	98.6	97.1	100.0	100.0	Jλ2/3	100.0	100.0	−
MAX10	VκI L9	99.6	100.0	100.0	100.0	98.7	100.0	Jκ2	100.0	100.0	−
HW1	VκI L1	99.3	97.9	99.5	98.6	98.7	96.0	Jκ3	97.4	100.0	−
RL1	VλI DPL2	100.0	100.0	100.0	100.0	100.0	100.0	Jλ2/3	100.0	100.0	−
EF16	VλI DPL5	99.3	99.0	99.5	100.0	98.9	96.6	Jλ2/3	94.6	91.7	−

mAb	V_L	Total			FR			CDR				JL
mAb	V_L			NA	AA	NA	AA	NA	AA			NA	AA	R
Hib PS inhibitable mAbs
MM1.5	VκII A2	98.0	96.0	98.6	96.7	96.7	95.7	Jκ3	100.0	100.0	+
MM4.1	VκII A2	98.3	97.0	99.0	96.7	96.7	97.1	Jκ3	100.0	100.0	+
Noninhibitable mAbs
MAX1	VκI L1	100.0	100.0	100.0	100.0	100.0	100.0	Jκ3	100.0	100.0	−
MAX4.	VκII A2	97.7	96.0	98.6	97.1	96.7	90.0	Jκ4	90.0	81.8	−
MAX5	VκIII L6	100.0	100.0	100.0	100.0	100.0	100.0	Jκ1	97.4	100.0	−
MAX6	VλVII DPL18	100.0	100.0	100.0	100.0	100.0	100.0	Jλ1	100.0	100.0	−
MAX8	VλI DPL2	98.0	98.0	98.6	97.1	100.0	100.0	Jλ2/3	100.0	100.0	−
MAX10	VκI L9	99.6	100.0	100.0	100.0	98.7	100.0	Jκ2	100.0	100.0	−
HW1	VκI L1	99.3	97.9	99.5	98.6	98.7	96.0	Jκ3	97.4	100.0	−
RL1	VλI DPL2	100.0	100.0	100.0	100.0	100.0	100.0	Jλ2/3	100.0	100.0	−
EF16	VλI DPL5	99.3	99.0	99.5	100.0	98.9	96.6	Jλ2/3	94.6	91.7	−

Shown are the most closely homologous germline V_L genes, percent homology of total genes, framework and CDR regions to candidate germline genes and their translated amino acid sequences, most closely homologous J segments, and presence of an arginine residue at the V_J joint.

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