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Table III.

Light chain variable region genes encoding anti-Hib PS mAbs from infantsa

mAbVLTotalFRCDRJL
NAAANAAANAAANAAAR
Hib PS inhibitable mAbs            
MM1.5 VκII A2 98.0 96.0 98.6 96.7 96.7 95.7 Jκ3 100.0 100.0 
MM4.1 VκII A2 98.3 97.0 99.0 96.7 96.7 97.1 Jκ3 100.0 100.0 
Noninhibitable mAbs            
MAX1 VκI L1 100.0 100.0 100.0 100.0 100.0 100.0 Jκ3 100.0 100.0 − 
MAX4. VκII A2 97.7 96.0 98.6 97.1 96.7 90.0 Jκ4 90.0 81.8 − 
MAX5 VκIII L6 100.0 100.0 100.0 100.0 100.0 100.0 Jκ1 97.4 100.0 − 
MAX6 VλVII DPL18 100.0 100.0 100.0 100.0 100.0 100.0 Jλ1 100.0 100.0 − 
MAX8 VλI DPL2 98.0 98.0 98.6 97.1 100.0 100.0 Jλ2/3 100.0 100.0 − 
MAX10 VκI L9 99.6 100.0 100.0 100.0 98.7 100.0 Jκ2 100.0 100.0 − 
HW1 VκI L1 99.3 97.9 99.5 98.6 98.7 96.0 Jκ3 97.4 100.0 − 
RL1 VλI DPL2 100.0 100.0 100.0 100.0 100.0 100.0 Jλ2/3 100.0 100.0 − 
EF16 VλI DPL5 99.3 99.0 99.5 100.0 98.9 96.6 Jλ2/3 94.6 91.7 − 
mAbVLTotalFRCDRJL
NAAANAAANAAANAAAR
Hib PS inhibitable mAbs            
MM1.5 VκII A2 98.0 96.0 98.6 96.7 96.7 95.7 Jκ3 100.0 100.0 
MM4.1 VκII A2 98.3 97.0 99.0 96.7 96.7 97.1 Jκ3 100.0 100.0 
Noninhibitable mAbs            
MAX1 VκI L1 100.0 100.0 100.0 100.0 100.0 100.0 Jκ3 100.0 100.0 − 
MAX4. VκII A2 97.7 96.0 98.6 97.1 96.7 90.0 Jκ4 90.0 81.8 − 
MAX5 VκIII L6 100.0 100.0 100.0 100.0 100.0 100.0 Jκ1 97.4 100.0 − 
MAX6 VλVII DPL18 100.0 100.0 100.0 100.0 100.0 100.0 Jλ1 100.0 100.0 − 
MAX8 VλI DPL2 98.0 98.0 98.6 97.1 100.0 100.0 Jλ2/3 100.0 100.0 − 
MAX10 VκI L9 99.6 100.0 100.0 100.0 98.7 100.0 Jκ2 100.0 100.0 − 
HW1 VκI L1 99.3 97.9 99.5 98.6 98.7 96.0 Jκ3 97.4 100.0 − 
RL1 VλI DPL2 100.0 100.0 100.0 100.0 100.0 100.0 Jλ2/3 100.0 100.0 − 
EF16 VλI DPL5 99.3 99.0 99.5 100.0 98.9 96.6 Jλ2/3 94.6 91.7 − 
a

Shown are the most closely homologous germline VL genes, percent homology of total genes, framework and CDR regions to candidate germline genes and their translated amino acid sequences, most closely homologous J segments, and presence of an arginine residue at the VJ joint.

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