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Table II.

Bcl-2 transgenic mice are partially protected from a lethal challenge with TNF/GalN and fully protected from a lethal challenge with anti-Fas

ChallengeaLethality (24 h)
Control miceTransgenic mice
0.1 μg TNF/20 mg GalN 0 /5 0/5 
0.3 μg TNF/20 mg GalN 4 /5 0/5b 
0.5 μg TNF/20 mg GalN 5 /5 5/5 
0.1 μg TNF/20 μg ActD 4 /5 3/5 
0.3 μg TNF/20 μg ActD 5 /5 5/5 
0.5 μg TNF/20 μg ActD 5 /5 5/5 
10 μg anti-Fas 2 /5 0/5 
15 μg anti-Fas 5 /5 0/5 
20 μg anti-Fas ND 0/5 
ChallengeaLethality (24 h)
Control miceTransgenic mice
0.1 μg TNF/20 mg GalN 0 /5 0/5 
0.3 μg TNF/20 mg GalN 4 /5 0/5b 
0.5 μg TNF/20 mg GalN 5 /5 5/5 
0.1 μg TNF/20 μg ActD 4 /5 3/5 
0.3 μg TNF/20 μg ActD 5 /5 5/5 
0.5 μg TNF/20 μg ActD 5 /5 5/5 
10 μg anti-Fas 2 /5 0/5 
15 μg anti-Fas 5 /5 0/5 
20 μg anti-Fas ND 0/5 
a

TNF/GalN and TNF/ActD were administered i.p., anti-Fas i.v. All doses were adjusted to 20 g of body weight.

b

, p = 0.0476 for transgenic vs wild-type mice.

c

, p = 0.0079 for transgenic vs wild-type mice.

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