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Table II.

Lymph node T cells and thymocytes from CD8mg transgenic, class II MHC-deficient micea

GenotypeNo. of Cells/ Thymus (× 106)Percent Lymph Node T CellsPercent Total ThymocytesPercent HSA-Thymocytes4:8 Ration
CD4+8.2 TCR+CD48.2+ TCR+TCR+ CD4+8.2TCR+ CD48.2+TCR+ CD4+8.2TCR+ CD48.2
Nontransgenic  35 ± 2.0 21 ± 1.1     1.7 
CD8mg transgenic  40 ± 1.5 20 ± 0.6     2.0 
Class II  1.6 ± 0.1 50 ± 1.8     0.033 10 
Class II/CD8mg transgenic  2.8 ± 0.2 50 ± 1.2     0.046 
Nontransgenic 224 ± 16   7.0 ± 0.2 5.2 ± 0.3 66 ± 0.5 20 ± 1.0 3.3 
CD8mg transgenic 174 ± 11   8.0 ± 0.5 6.2 ± 0.5 61 ± 0.9 25 ± 0.9 2.4 
Class II 197 ± 15   1.1 ± 0.2 6.8 ± 0.3 5.0 ± 0.2 71 ± 2.0 0.068 10 
Class II/CD8mg transgenic 209 ± 18   1.6 ± 0.1 7.0 ± 0.6 7.1 ± 0.4 74 ± 1.5 0.096 
GenotypeNo. of Cells/ Thymus (× 106)Percent Lymph Node T CellsPercent Total ThymocytesPercent HSA-Thymocytes4:8 Ration
CD4+8.2 TCR+CD48.2+ TCR+TCR+ CD4+8.2TCR+ CD48.2+TCR+ CD4+8.2TCR+ CD48.2
Nontransgenic  35 ± 2.0 21 ± 1.1     1.7 
CD8mg transgenic  40 ± 1.5 20 ± 0.6     2.0 
Class II  1.6 ± 0.1 50 ± 1.8     0.033 10 
Class II/CD8mg transgenic  2.8 ± 0.2 50 ± 1.2     0.046 
Nontransgenic 224 ± 16   7.0 ± 0.2 5.2 ± 0.3 66 ± 0.5 20 ± 1.0 3.3 
CD8mg transgenic 174 ± 11   8.0 ± 0.5 6.2 ± 0.5 61 ± 0.9 25 ± 0.9 2.4 
Class II 197 ± 15   1.1 ± 0.2 6.8 ± 0.3 5.0 ± 0.2 71 ± 2.0 0.068 10 
Class II/CD8mg transgenic 209 ± 18   1.6 ± 0.1 7.0 ± 0.6 7.1 ± 0.4 74 ± 1.5 0.096 
a

Total thymocytes, mature thymocytes (HSA depleted), or lymph node T cells were stained with Abs against TCR, CD4, and CD8.2 (endogenous CD8) as described in Materials and Methods. Average values and SDs are given, and n is the number of mice of each genotype analyzed.

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