Distribution of Vλ gene clusters from individual B cells in an SLE patient compared to normals
| Cluster . | Known Functional Genes per VL Gene Cluster (% of total) . | SLE . | . | Normals . | . | ||
|---|---|---|---|---|---|---|---|
| . | . | Nonproductive No. (% of total) . | Productive No. (% of total) . | Nonproductive No. (% of total) . | Productive No. (% of total) . | ||
| A | 14 (46.7) | 22 (37.9) | 35† (33.7)a | 15 (34.9) | 84 (48.8)a | ||
| B | 11 (36.7) | 21 (36.2) | 37 (35.6) | 16 (37.2) | 64 (37.2) | ||
| C | 5 (16.7) | 15 (25.9) | 32b (30.8)a | 12b (27.9) | 24 (14.0)a | ||
| Total | 30 | 58 | 104 | 43 | 172 | ||
| Cluster . | Known Functional Genes per VL Gene Cluster (% of total) . | SLE . | . | Normals . | . | ||
|---|---|---|---|---|---|---|---|
| . | . | Nonproductive No. (% of total) . | Productive No. (% of total) . | Nonproductive No. (% of total) . | Productive No. (% of total) . | ||
| A | 14 (46.7) | 22 (37.9) | 35† (33.7)a | 15 (34.9) | 84 (48.8)a | ||
| B | 11 (36.7) | 21 (36.2) | 37 (35.6) | 16 (37.2) | 64 (37.2) | ||
| C | 5 (16.7) | 15 (25.9) | 32b (30.8)a | 12b (27.9) | 24 (14.0)a | ||
| Total | 30 | 58 | 104 | 43 | 172 | ||
Significant differences between the frequency in the productive and nonproductive repertoires, respectively, between the SLE patient and the normals (χ2 test) (nonproductive: p < 0.05 for cluster C; productive: cluster A, p = 0.04; cluster C, p = 0.001).
, p ≤ 0.05, significantly higher frequency than predicted from its presence in the genome (goodness of fit χ2 test); †, p ≤ 0.05, significantly lower frequency than predicted from its presence in the genome (goodness of fit χ2 test).