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Table IV.

Distribution of Vλ gene clusters from individual B cells in an SLE patient compared to normals

ClusterKnown Functional Genes per VL Gene Cluster (% of total)SLENormals
Nonproductive No. (% of total)Productive No. (% of total)Nonproductive No. (% of total)Productive No. (% of total)
14 (46.7) 22 (37.9) 35 (33.7)a 15 (34.9) 84 (48.8)a 
11 (36.7) 21 (36.2) 37 (35.6) 16 (37.2) 64 (37.2) 
5 (16.7) 15 (25.9) 32b (30.8)a 12b (27.9) 24 (14.0)a 
      
Total 30 58 104 43 172 
ClusterKnown Functional Genes per VL Gene Cluster (% of total)SLENormals
Nonproductive No. (% of total)Productive No. (% of total)Nonproductive No. (% of total)Productive No. (% of total)
14 (46.7) 22 (37.9) 35 (33.7)a 15 (34.9) 84 (48.8)a 
11 (36.7) 21 (36.2) 37 (35.6) 16 (37.2) 64 (37.2) 
5 (16.7) 15 (25.9) 32b (30.8)a 12b (27.9) 24 (14.0)a 
      
Total 30 58 104 43 172 
a

Significant differences between the frequency in the productive and nonproductive repertoires, respectively, between the SLE patient and the normals (χ2 test) (nonproductive: p < 0.05 for cluster C; productive: cluster A, p = 0.04; cluster C, p = 0.001).

b

, p ≤ 0.05, significantly higher frequency than predicted from its presence in the genome (goodness of fit χ2 test); †, p ≤ 0.05, significantly lower frequency than predicted from its presence in the genome (goodness of fit χ2 test).

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