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Table II.

Effect of Ad dl327a on TNFRII-deficient and TNFRI/RII-deficient mice

Expt.Number of Dead Miceb /Total Number per Experiment
TNFRII deficientTNFRI/RII deficient
4 /5 0 /5 
3 /5 0 /5 
3a 2 /5 0 /5 
3bc 0 /5 0 /5 
Expt.Number of Dead Miceb /Total Number per Experiment
TNFRII deficientTNFRI/RII deficient
4 /5 0 /5 
3 /5 0 /5 
3a 2 /5 0 /5 
3bc 0 /5 0 /5 
a

dl327 lethal dose was determined in wt mice immediately prior to each experiment and ranged from 2 × 108 IU to 8 × 108 injected i.p.

b

Mouse deaths occurred between days 2 and 4 p.i. The experiment was terminated on day 5 p.i.

c

Ad5 wt was used in this experiment at the same dose as dl327 (4 × 108 IU).

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