Effect of Ad dl327a on TNFRII-deficient and TNFRI/RII-deficient mice
| Expt. . | Number of Dead Miceb /Total Number per Experiment . | . | |
|---|---|---|---|
| . | TNFRII deficient . | TNFRI/RII deficient . | |
| 1 | 4 /5 | 0 /5 | |
| 2 | 3 /5 | 0 /5 | |
| 3a | 2 /5 | 0 /5 | |
| 3bc | 0 /5 | 0 /5 | |
| Expt. . | Number of Dead Miceb /Total Number per Experiment . | . | |
|---|---|---|---|
| . | TNFRII deficient . | TNFRI/RII deficient . | |
| 1 | 4 /5 | 0 /5 | |
| 2 | 3 /5 | 0 /5 | |
| 3a | 2 /5 | 0 /5 | |
| 3bc | 0 /5 | 0 /5 | |
dl327 lethal dose was determined in wt mice immediately prior to each experiment and ranged from 2 × 108 IU to 8 × 108 injected i.p.
Mouse deaths occurred between days 2 and 4 p.i. The experiment was terminated on day 5 p.i.
Ad5 wt was used in this experiment at the same dose as dl327 (4 × 108 IU).