American Association of Immunologists

Table II.

aPL share Ig V genes with other anti-DNA autoantibodies in SLE

Germline V Gene^a	aPL			Patient-Derived Autoantibody^b
Germline V Gene^a		Name	Homology (%)	Name	Homology (%)
VH26 VH3	B14	92	18/2 IgM anti-DNA	100
4.33 VH4	P11	93	None	n/a
VH6	B22	94	A10 IgM anti-DNA	99
A20 VK1	B14, B22	96, 98	III-2R IgM anti-DNA	100
A30 VK1	P11	95	SC17 IgG anti-DNA	98
L5 VK1	P13	93	NE-13 IgM anti-DNA	100
L15 VK1	B27	96	None	n/a

Germline V Gene^a	aPL			Patient-Derived Autoantibody^b
Germline V Gene^a		Name	Homology (%)	Name	Homology (%)
VH26 VH3	B14	92	18/2 IgM anti-DNA	100
4.33 VH4	P11	93	None	n/a
VH6	B22	94	A10 IgM anti-DNA	99
A20 VK1	B14, B22	96, 98	III-2R IgM anti-DNA	100
A30 VK1	P11	95	SC17 IgG anti-DNA	98
L5 VK1	P13	93	NE-13 IgM anti-DNA	100
L15 VK1	B27	96	None	n/a

The references for germline Ig V genes are VH26 (29), 4.33 (31), VH6 (30), A20 (34), A30 (35), L5 (33), and L15 (32).

The references for patient-derived autoantibodies are 18/2 (41), A10 (42), III-2R (43), SC17 (40), and NE13 (44).