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Table II.

aPL share Ig V genes with other anti-DNA autoantibodies in SLE

Germline V GeneaaPLPatient-Derived Autoantibodyb
NameHomology (%)NameHomology (%)
VH26 VH3 B14 92 18/2 IgM anti-DNA 100 
4.33 VH4 P11 93 None n/a 
VH6 B22 94 A10 IgM anti-DNA 99 
A20 VK1 B14, B22 96, 98 III-2R IgM anti-DNA 100 
A30 VK1 P11 95 SC17 IgG anti-DNA 98 
L5 VK1 P13 93 NE-13 IgM anti-DNA 100 
L15 VK1 B27 96 None n/a 
Germline V GeneaaPLPatient-Derived Autoantibodyb
NameHomology (%)NameHomology (%)
VH26 VH3 B14 92 18/2 IgM anti-DNA 100 
4.33 VH4 P11 93 None n/a 
VH6 B22 94 A10 IgM anti-DNA 99 
A20 VK1 B14, B22 96, 98 III-2R IgM anti-DNA 100 
A30 VK1 P11 95 SC17 IgG anti-DNA 98 
L5 VK1 P13 93 NE-13 IgM anti-DNA 100 
L15 VK1 B27 96 None n/a 
a

The references for germline Ig V genes are VH26 (29), 4.33 (31), VH6 (30), A20 (34), A30 (35), L5 (33), and L15 (32).

b

The references for patient-derived autoantibodies are 18/2 (41), A10 (42), III-2R (43), SC17 (40), and NE13 (44).

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