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Table II.

CD4 T cell subset baseline and turnover

Defining mAb CombinationSubsetBaseline, cells/μl (mean ± SD)Slope, cells/μl/day (mean ± SD)p Valuea
CD4, CD3, CD45 CD4 153 ± 199 3.66 ± 1.74  
CD4, CD45RA, CD45RO CD4:RA 48 ± 85 1.03 ± 1.43   
 CD4:RA/RO 14 ± 27 0.08 ± 0.18 0.0494 
 CD4:RO 90 ± 96 2.56 ± 1.71  
CD4, CD45RA, CD62L CD4:RA CD62L+ 57 ± 105 1.03 ± 1.38  0.0052 
 CD4:RA CD62L− 2 ± 3 0.04 ± 0.07  
 CD4:RO CD62L+ 73 ± 84 2.03 ± 1.41  0.0006 
 CD4:RO CD62L− 21 ± 21 0.57 ± 0.49  
CD4, CD45RO, CD44 CD4:RA 44-low 59 ± 111 1.14 ± 1.59  0.0023 
 CD4:RA 44-high 1 ± 1 0.06 ± 0.11  
 CD4:RO 44-low 62 ± 52 2.12 ± 1.49  0.0004 
 CD4:RO 44-high 31 ± 45 0.34 ± 0.75  
CD4, CD45RA, CD38 CD4:RA CD38+ 60 ± 105 1.21 ± 1.49  0.0002 
 CD4:RA CD38− 2 ± 5 −0.02 ± 0.13  
 CD4:RO CD38+ 60 ± 62 2.03 ± 1.53  0.0017 
 CD4:RO CD38− 31 ± 38 0.45 ± 0.46  
CD4, CD45RA, CD25 CD4:RA CD25+ 9 ± 16 0.26 ± 0.42  0.0052 
 CD4:RA CD25− 52 ± 93 0.80 ± 1.05  
 CD4:RO CD25+ 37 ± 40 0.99 ± 0.83  NS 
 CD4:RO CD25− 55 ± 63 1.61 ± 1.57  
CD4, CD45RA, HLA DR CD4:RA HLA DR+ 3 ± 3 0.09 ± 0.12  0.0278 
 CD4:RA HLA DR− 58 ± 106 1.08 ± 1.49  
 CD4:RO HLA DR+ 29 ± 24 1.36 ± 1.43  NS 
 CD4:RO HLA DR− 63 ± 80 1.13 ± 0.81  
CD4, CD62L CD4 CD62L+ 130 ± 179 3.06 ± 1.70  0.0006 
 CD4 CD62L− 23 ± 23 0.61 ± 0.51  
CD4, CD44 CD4 CD44-low 121 ± 157 3.27 ± 1.94  0.0006 
 CD4 CD44-high 32 ± 46 0.40 ± 0.71  
CD4, CD38 CD4 CD38+ 120 ± 160 3.24 ± 1.62  0.0001 
 CD4 CD38− 33 ± 41 0.42 ± 0.53  
CD4, CD25 CD4 CD25+ 46 ± 53 1.25 ± 1.11  NS 
 CD4 CD25− 107 ± 149 2.41 ± 1.34  
CD4, HLA DR CD4 HLA DR+ 32 ± 26 1.45 ± 1.47  NS 
 CD4 HLA DR− 121 ± 180 2.22 ± 1.82  
Defining mAb CombinationSubsetBaseline, cells/μl (mean ± SD)Slope, cells/μl/day (mean ± SD)p Valuea
CD4, CD3, CD45 CD4 153 ± 199 3.66 ± 1.74  
CD4, CD45RA, CD45RO CD4:RA 48 ± 85 1.03 ± 1.43   
 CD4:RA/RO 14 ± 27 0.08 ± 0.18 0.0494 
 CD4:RO 90 ± 96 2.56 ± 1.71  
CD4, CD45RA, CD62L CD4:RA CD62L+ 57 ± 105 1.03 ± 1.38  0.0052 
 CD4:RA CD62L− 2 ± 3 0.04 ± 0.07  
 CD4:RO CD62L+ 73 ± 84 2.03 ± 1.41  0.0006 
 CD4:RO CD62L− 21 ± 21 0.57 ± 0.49  
CD4, CD45RO, CD44 CD4:RA 44-low 59 ± 111 1.14 ± 1.59  0.0023 
 CD4:RA 44-high 1 ± 1 0.06 ± 0.11  
 CD4:RO 44-low 62 ± 52 2.12 ± 1.49  0.0004 
 CD4:RO 44-high 31 ± 45 0.34 ± 0.75  
CD4, CD45RA, CD38 CD4:RA CD38+ 60 ± 105 1.21 ± 1.49  0.0002 
 CD4:RA CD38− 2 ± 5 −0.02 ± 0.13  
 CD4:RO CD38+ 60 ± 62 2.03 ± 1.53  0.0017 
 CD4:RO CD38− 31 ± 38 0.45 ± 0.46  
CD4, CD45RA, CD25 CD4:RA CD25+ 9 ± 16 0.26 ± 0.42  0.0052 
 CD4:RA CD25− 52 ± 93 0.80 ± 1.05  
 CD4:RO CD25+ 37 ± 40 0.99 ± 0.83  NS 
 CD4:RO CD25− 55 ± 63 1.61 ± 1.57  
CD4, CD45RA, HLA DR CD4:RA HLA DR+ 3 ± 3 0.09 ± 0.12  0.0278 
 CD4:RA HLA DR− 58 ± 106 1.08 ± 1.49  
 CD4:RO HLA DR+ 29 ± 24 1.36 ± 1.43  NS 
 CD4:RO HLA DR− 63 ± 80 1.13 ± 0.81  
CD4, CD62L CD4 CD62L+ 130 ± 179 3.06 ± 1.70  0.0006 
 CD4 CD62L− 23 ± 23 0.61 ± 0.51  
CD4, CD44 CD4 CD44-low 121 ± 157 3.27 ± 1.94  0.0006 
 CD4 CD44-high 32 ± 46 0.40 ± 0.71  
CD4, CD38 CD4 CD38+ 120 ± 160 3.24 ± 1.62  0.0001 
 CD4 CD38− 33 ± 41 0.42 ± 0.53  
CD4, CD25 CD4 CD25+ 46 ± 53 1.25 ± 1.11  NS 
 CD4 CD25− 107 ± 149 2.41 ± 1.34  
CD4, HLA DR CD4 HLA DR+ 32 ± 26 1.45 ± 1.47  NS 
 CD4 HLA DR− 121 ± 180 2.22 ± 1.82  
a

Wilcoxon signed rank test comparison of slopes of designated CD4 T cell subsets. NS, not significant (p > 0.05).

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