Linear peptide (NPNEPS)-induced protection (A/J mice) is CD4+ T cell and IFN-γ dependent but IL-12 and NO independent
| Expt. . | Treatmenta . | No. Protected/No. Challenged . | % Protection . | p Valueb . |
|---|---|---|---|---|
| 1 | Control Ab | 11 /13 | 85 | |
| Anti-IL-12 mAb | 10 /11 | 91 | 1.000 | |
| 2 | Control Ab | 5 /7 | 71 | |
| Anti-IFN-γ mAb | 0 /7 | 0 | 0.021 | |
| Anti-iNOS | 6 /7 | 86 | 1.000 |
| Expt. . | Treatmenta . | No. Protected/No. Challenged . | % Protection . | p Valueb . |
|---|---|---|---|---|
| 1 | Control Ab | 11 /13 | 85 | |
| Anti-IL-12 mAb | 10 /11 | 91 | 1.000 | |
| 2 | Control Ab | 5 /7 | 71 | |
| Anti-IFN-γ mAb | 0 /7 | 0 | 0.021 | |
| Anti-iNOS | 6 /7 | 86 | 1.000 |
All adjuvant control mice treated with control Ab (n = 16) or anti-IL-12 mAb (n = 16) developed patent blood-stage parasitemia.
Values of p were calculated by comparing protection with test treatment versus control, in each experiment, using Fisher’s exact test (two-tailed).