The incidence of diabetes in NOD.Ins-IL-10 mice is not regulated by BALB/c-derived MHC class II molecules
| No. of Mice . | H-2 Haplotype . | . | . | Incidence of IDDM at 8 wk of Agea . | % Protection . | ||
|---|---|---|---|---|---|---|---|
| . | I-Ad . | I-Ed . | Dd . | . | . | ||
| 12 | − | − | − | 12 /12 | 0 | ||
| 3 | + | − | − | 3 /3 | 0 | ||
| 4 | + | − | + | 0 /4 | 100 | ||
| 3 | − | + | − | 3 /3 | 0 | ||
| 5 | − | + | + | 0 /5 | 100 | ||
| 1 | + | + | − | 1 /1 | 0 | ||
| 9 | + | + | + | 0 /9 | 100 | ||
| No. of Mice . | H-2 Haplotype . | . | . | Incidence of IDDM at 8 wk of Agea . | % Protection . | ||
|---|---|---|---|---|---|---|---|
| . | I-Ad . | I-Ed . | Dd . | . | . | ||
| 12 | − | − | − | 12 /12 | 0 | ||
| 3 | + | − | − | 3 /3 | 0 | ||
| 4 | + | − | + | 0 /4 | 100 | ||
| 3 | − | + | − | 3 /3 | 0 | ||
| 5 | − | + | + | 0 /5 | 100 | ||
| 1 | + | + | − | 1 /1 | 0 | ||
| 9 | + | + | + | 0 /9 | 100 | ||
Blood glucose level was measured at weekly intervals starting at 4 wk of age from N7 to N11 backcross generations of NOD.Ins-IL-10 mice. Mice with a blood glucose level ≥300 mg/dl were considered diabetic.