Effects of anti-C5a on parameters of MOF
| Organ . | Parameter . | Groups . | . | . | ||
|---|---|---|---|---|---|---|
| . | . | Sham + preimmune IgG . | CLP + preimmune IgG . | CLP + anti-C5a . | ||
| Blood | Lactate (nmol/L) | 2.87 ± 0.40 | 7.42 ± 1.31 | 3.54 ± 0.30 | ||
| Liver | Bilirubin (mg/dl) | 0.30 ± 0.01 | 0.53 ± 0.08 | 0.23 ± 0.03 | ||
| ALT (U/L) | 46.6 ± 1.8 | 255.0 ± 65.2 | 63.6 ± 2.4 | |||
| AST (U/L) | 74.0 ± 2.0 | 386.6 ± 71.6 | 128.0 ± 8.5 | |||
| LDH (U/L) | 288.3 ± 85.8 | 926.0 ± 47.0 | 628.0 ± 11.5 | |||
| Kidney | Creatinine (mg/dl) | 0.43 ± 0.03 | 0.70 ± 0.05 | 0.43 ± 0.06 | ||
| BUN (mg/dl) | 11.6 ± 1.4 | 44.5 ± 12.2 | 17.6 ± 0.7 | |||
| Urine protein (mg/dl) | 1.30 ± 0.04 | 3.27 ± 0.29 | 1.57 ± 0.19 | |||
| Urine output (ml/36 h) | 26.2 ± 0.8 | 6.6 ± 1.0 | 19.0 ± 1.0 | |||
| GFR (ml/min) | 1.89 ± 0.03 | 0.49 ± 0.07 | 1.90 ± 0.24 | |||
| Organ . | Parameter . | Groups . | . | . | ||
|---|---|---|---|---|---|---|
| . | . | Sham + preimmune IgG . | CLP + preimmune IgG . | CLP + anti-C5a . | ||
| Blood | Lactate (nmol/L) | 2.87 ± 0.40 | 7.42 ± 1.31 | 3.54 ± 0.30 | ||
| Liver | Bilirubin (mg/dl) | 0.30 ± 0.01 | 0.53 ± 0.08 | 0.23 ± 0.03 | ||
| ALT (U/L) | 46.6 ± 1.8 | 255.0 ± 65.2 | 63.6 ± 2.4 | |||
| AST (U/L) | 74.0 ± 2.0 | 386.6 ± 71.6 | 128.0 ± 8.5 | |||
| LDH (U/L) | 288.3 ± 85.8 | 926.0 ± 47.0 | 628.0 ± 11.5 | |||
| Kidney | Creatinine (mg/dl) | 0.43 ± 0.03 | 0.70 ± 0.05 | 0.43 ± 0.06 | ||
| BUN (mg/dl) | 11.6 ± 1.4 | 44.5 ± 12.2 | 17.6 ± 0.7 | |||
| Urine protein (mg/dl) | 1.30 ± 0.04 | 3.27 ± 0.29 | 1.57 ± 0.19 | |||
| Urine output (ml/36 h) | 26.2 ± 0.8 | 6.6 ± 1.0 | 19.0 ± 1.0 | |||
| GFR (ml/min) | 1.89 ± 0.03 | 0.49 ± 0.07 | 1.90 ± 0.24 | |||