Table III.

Lymphoid organ weights and cellular subsets in TCRα−/− male BXSB recipients of WT male or female CD3+ cells

SpleenLNCD4+ SubsetsCD8+ SubsetsCD19+Mac-1+ Peripheral Blood
CD4+CD4+CD44highCD8+CD8+CD44high
Male BXSB→male BXSB TCRα−/− 0.4 ± 0.05 0.4 ± 0.1 13.7 ± 0.5b 83.0 ± 1.8 3.4 ± 0.3 71.4 ± 1.4 58.9 ± 1.2 25.1 ± 2.8 
Female BXSB→male BXSB TCRα−/− 0.4 ± 0.1 0.3 ± 0.1 16.6 ± 0.7 84.6 ± 1.7 2.4 ± 0.4 69.3 ± 3.4 54.6 ± 2.2 18.5 ± 2.9 
WT male BXSB 0.38 ± 0.1 0.45 ± 0.05 16.8 ± 1.9 88.4 ± 4.0 2.7 ± 0.22 84.2 ± 2.1 79.2 ± 2.4** 23.7 ± 4.8 
SpleenLNCD4+ SubsetsCD8+ SubsetsCD19+Mac-1+ Peripheral Blood
CD4+CD4+CD44highCD8+CD8+CD44high
Male BXSB→male BXSB TCRα−/− 0.4 ± 0.05 0.4 ± 0.1 13.7 ± 0.5b 83.0 ± 1.8 3.4 ± 0.3 71.4 ± 1.4 58.9 ± 1.2 25.1 ± 2.8 
Female BXSB→male BXSB TCRα−/− 0.4 ± 0.1 0.3 ± 0.1 16.6 ± 0.7 84.6 ± 1.7 2.4 ± 0.4 69.3 ± 3.4 54.6 ± 2.2 18.5 ± 2.9 
WT male BXSB 0.38 ± 0.1 0.45 ± 0.05 16.8 ± 1.9 88.4 ± 4.0 2.7 ± 0.22 84.2 ± 2.1 79.2 ± 2.4** 23.7 ± 4.8 
a

Spleen and LN (axillary, inguinal, cervical, and mesenteric) weights (in grams) of 4-mo-old WT male BXSB and of 9-mo-old αβ+ T cell-deficient male BXSB recipients of WT male or female CD3+ LN T cells. Lymphoid subsets are in percentages of total splenocytes or PBMC (mean ± SEM of five to eight mice per group) and, in the case of CD44high cells, as percentages of CD4+ or CD8+ cells.

b

, p < 0.05 between male BXSB→male BXSB TCRα−/− mice and either of the other groups.

c

∗, p < 0.05 between the WT male BXSB mice and either male TCRα−/− recipient groups.

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