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Table I.

Names and genotypes of various chimeric and germline mutant mice

NameGenotype
+/Vβ(neo) Heterozygous Vβ insertion with the PGK-neo 
Vβ/Vβ(neo) Homozygous Vβ insertion with the PGK-neo 
+/Vβ(Δneo) Heterozygous Vβ insertion without the PGK-neo 
Vβ/Vβ(Δneo) Homozygous Vβ insertion without the PGK-neo 
+/Vβ(neo);tg-5a Heterozygous Vβ insertion with the PGK-neo and a TCRβ transgene 
+/Vβ(Δneo);tg-5 Heterozygous Vβ insertion without the PGK-neo but with a TCRβ transgene 
Vβ/Vβ(neo);tg-3 Homozygous Vβ insertion with the PGK-neo and a TCRβ transgene 
Vβ/Vβ(Δneo);tg-2 Heterozygous Vβ insertion without the PGK-neo but with a TCRβ transgene 
+/+;tg-5 Wild-type mice with a TCRβ transgene 
NameGenotype
+/Vβ(neo) Heterozygous Vβ insertion with the PGK-neo 
Vβ/Vβ(neo) Homozygous Vβ insertion with the PGK-neo 
+/Vβ(Δneo) Heterozygous Vβ insertion without the PGK-neo 
Vβ/Vβ(Δneo) Homozygous Vβ insertion without the PGK-neo 
+/Vβ(neo);tg-5a Heterozygous Vβ insertion with the PGK-neo and a TCRβ transgene 
+/Vβ(Δneo);tg-5 Heterozygous Vβ insertion without the PGK-neo but with a TCRβ transgene 
Vβ/Vβ(neo);tg-3 Homozygous Vβ insertion with the PGK-neo and a TCRβ transgene 
Vβ/Vβ(Δneo);tg-2 Heterozygous Vβ insertion without the PGK-neo but with a TCRβ transgene 
+/+;tg-5 Wild-type mice with a TCRβ transgene 
a

tg-5 represents the germline TCRβ-transgenic mouse strain; the others, indicated by different numbers, are chimeric mice generated with different ES cell clones carrying the same TCRβ transgene but at different integration sites.

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