Comparison of typhlocolitis in H. hepaticus-infected NF-κB-deficient and WT micea
| . | WT (n = 15) . | p50+/+p65+/− (n = 10) . | p50−/−p65+/+ (n = 15) . | p50−/−p65+/− (n = 19) . |
|---|---|---|---|---|
| Cecum | 1 (0–2)b | 1 (1–2) | 3 (2–4) | 4 (3–4) |
| p = 0.3490 | p < 0.00001c | p < 0.00001c | ||
| p = 0.0007d | ||||
| Colon | 1 (0–2) | 1 (1–2) | 3 (2–3) | 4 (3–4) |
| p = 0.1481 | p = 0.0001c | p < 0.00001c | ||
| p < 0.00001d |
| . | WT (n = 15) . | p50+/+p65+/− (n = 10) . | p50−/−p65+/+ (n = 15) . | p50−/−p65+/− (n = 19) . |
|---|---|---|---|---|
| Cecum | 1 (0–2)b | 1 (1–2) | 3 (2–4) | 4 (3–4) |
| p = 0.3490 | p < 0.00001c | p < 0.00001c | ||
| p = 0.0007d | ||||
| Colon | 1 (0–2) | 1 (1–2) | 3 (2–3) | 4 (3–4) |
| p = 0.1481 | p = 0.0001c | p < 0.00001c | ||
| p < 0.00001d |
Inflammation and hyperplasia of cecum and colon were evaluated histologically and scored 0–4 as described in the text. Data were subjected to the Mann-Whitney U test by comparison of each NF-κB mutant and WT or p50−/−. Data are presented as median score and range. Typhlitis (p50−/− and p50−/−p65+/−) and colitis (p50−/− and p50−/−p65+/−) were significantly elevated compared to infected WT mice, and typhlitis (p50−/−p65+/−) and colitis (p50−/−p65+/−) were significantly elevated compared to infected p50−/− mice.
Median score (range).
Mann-Whitney U test, comparison to H. hepaticus-infected WT value.
Mann-Whitney U test, comparison to H. hepaticus-infected p50−/− value.