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Table I.

Proliferative responses of CD4−CD8− 1H3 T cells to Ea52-68 in the presence of IL-2a

Donor MouseStimulation Index
1H3.1 TCR Tg 15.2 
1H3.1 TCR Tg I-Aβb−/− 9 
1H3.1 TCR Tg Ii−/− 58 
Donor MouseStimulation Index
1H3.1 TCR Tg 15.2 
1H3.1 TCR Tg I-Aβb−/− 9 
1H3.1 TCR Tg Ii−/− 58 
a

Proliferation of sorted Vβ6+CD4−CD8−T cells from 1H3.1 TCR Tg, 1H3.1 TCR Tg I-Aβb−/−, and 1H3.1 TCR Tg Ii−/− litterrnates cultured 3 days in the presence of irradiated B10.A(5R) APCs plus IL-2. The stimulation index was calculated as follows: cpm (T cells + APCs + IL-2) − (cpm (T cells + IL-2) + cpm APCs)/(cpm (T cells + IL-2) + cpm APCs).

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