Autoantibody production in male and female Aiolos-deficient micea
| . | Males . | . | Females . | . | ||
|---|---|---|---|---|---|---|
| . | WT . | Aiolos−/− . | WT . | Aiolos−/− . | ||
| Anti-ANA | 30 (10) | 53 (17) | 8 (11) | 89 (9) | ||
| Anti-ssDNA | 30 (10) | 56 (16) | 27 (11) | 70 (10) | ||
| Anti-dsDNA | 6 (16) | 77 (26) | 13 (15) | 87 (23) | ||
| Anti-histone | 10 (10) | 53 (15) | 7 (11) | 33 (9) | ||
| . | Males . | . | Females . | . | ||
|---|---|---|---|---|---|---|
| . | WT . | Aiolos−/− . | WT . | Aiolos−/− . | ||
| Anti-ANA | 30 (10) | 53 (17) | 8 (11) | 89 (9) | ||
| Anti-ssDNA | 30 (10) | 56 (16) | 27 (11) | 70 (10) | ||
| Anti-dsDNA | 6 (16) | 77 (26) | 13 (15) | 87 (23) | ||
| Anti-histone | 10 (10) | 53 (15) | 7 (11) | 33 (9) | ||
The percentage of positive for a specific autoantibody is shown. The number of mice analyzed (3–7 mo old) is given in parentheses. Serum autoantibodies were detected by ELISA. The mean ± 2 SD of the OD from WT mice was set as the lower limit for a sample to be scored as positive.