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Table II.

Autoantibody production in male and female Aiolos-deficient micea

MalesFemales
WTAiolos−/−WTAiolos−/−
Anti-ANA 30 (10) 53 (17) 8 (11) 89 (9) 
Anti-ssDNA 30 (10) 56 (16) 27 (11) 70 (10) 
Anti-dsDNA 6 (16) 77 (26) 13 (15) 87 (23) 
Anti-histone 10 (10) 53 (15) 7 (11) 33 (9) 
MalesFemales
WTAiolos−/−WTAiolos−/−
Anti-ANA 30 (10) 53 (17) 8 (11) 89 (9) 
Anti-ssDNA 30 (10) 56 (16) 27 (11) 70 (10) 
Anti-dsDNA 6 (16) 77 (26) 13 (15) 87 (23) 
Anti-histone 10 (10) 53 (15) 7 (11) 33 (9) 
a

The percentage of positive for a specific autoantibody is shown. The number of mice analyzed (3–7 mo old) is given in parentheses. Serum autoantibodies were detected by ELISA. The mean ± 2 SD of the OD from WT mice was set as the lower limit for a sample to be scored as positive.

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