Table I.

Frequency of CD11b+ DCs in the dome regions of Peyer’s patches of various CCR6 knockout mice and their littermate controls

Mouse StrainCCR6 GenotypeNo. of Mice ExaminedNo. Domes ExaminedaAverage No. of CD11b+ DC/Dome ± STDp Value
−/− 18 15 ± 10.4 0.62 
+/+ 20 12.7 ± 9.6  
−/− 12 ± 4.2 0.44 
+/+ 8 ± 4.2  
−/− 15 24 15.2 ± 8.4 0.66 
+/+ 15 36 16.7 ± 9.5  
−/− 25.5 ± 16.2 0.67 
+/+ 19 ± 6.8  
Mouse StrainCCR6 GenotypeNo. of Mice ExaminedNo. Domes ExaminedaAverage No. of CD11b+ DC/Dome ± STDp Value
−/− 18 15 ± 10.4 0.62 
+/+ 20 12.7 ± 9.6  
−/− 12 ± 4.2 0.44 
+/+ 8 ± 4.2  
−/− 15 24 15.2 ± 8.4 0.66 
+/+ 15 36 16.7 ± 9.5  
−/− 25.5 ± 16.2 0.67 
+/+ 19 ± 6.8  
a

Frozen sections of mice from each group were doubly labeled with anti-CD11c (green) and anti-CD11b (red) and the number of double-positive cells (yellow) were counted under the fluorescence microscope. Only the dome regions of Peyer’s patches that were cut through the center of the dome perpendicular to the tunica muscularis were used in determining the number of CD11b+ DCs. The number of CD11b+ DCs in such dome regions differed between 0 and 37.

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