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Table II.

Estimate of number of epitope-specific CD8 T cell clonotypes per infected spleen

MouseVβ13, Vβ5, or Vβ8 Epitope-Specific Cells/Spleen (no.)α(P)aFrequency of Vβ13, Vβ5, or Vβ8 clonotypes (per 10,000)bTotal No. of Vβ13, Vβ5, Vβ8 Clonotypes/Infected Spleen (CI)bTotal No. of Clonotypes/Spleenc
JHM S510-1 Vβ13 310,000 27.08 (0.60) 160 253 (170–333) 1,150 
 Vβ8 197,000 22.80 (0.043) 139 206 (139–271) 1,471 
S510-2 Vβ13 438,000 35.42 (0.73) 200 334 (226–437) 1,518 
JHM S598-1 Vβ5 160,000 24.70 (0.87) 148 217 (141–289) 775 
S598-2 Vβ5 350,000 26.27 (0.23) 156 249 (163–332) 889 
S598-3 Vβ5 1,030,000 14.59 (0.24) 95 163 (100–224) 582 
LCMV gp33–1 Vβ8 1,280,000 29.5 (0.95) 172 315 (223–404) 1,050 
gp33-2 Vβ8 2,510,000 32.7 (0.78) 187 368 (264–469) 1,227 
MouseVβ13, Vβ5, or Vβ8 Epitope-Specific Cells/Spleen (no.)α(P)aFrequency of Vβ13, Vβ5, or Vβ8 clonotypes (per 10,000)bTotal No. of Vβ13, Vβ5, Vβ8 Clonotypes/Infected Spleen (CI)bTotal No. of Clonotypes/Spleenc
JHM S510-1 Vβ13 310,000 27.08 (0.60) 160 253 (170–333) 1,150 
 Vβ8 197,000 22.80 (0.043) 139 206 (139–271) 1,471 
S510-2 Vβ13 438,000 35.42 (0.73) 200 334 (226–437) 1,518 
JHM S598-1 Vβ5 160,000 24.70 (0.87) 148 217 (141–289) 775 
S598-2 Vβ5 350,000 26.27 (0.23) 156 249 (163–332) 889 
S598-3 Vβ5 1,030,000 14.59 (0.24) 95 163 (100–224) 582 
LCMV gp33–1 Vβ8 1,280,000 29.5 (0.95) 172 315 (223–404) 1,050 
gp33-2 Vβ8 2,510,000 32.7 (0.78) 187 368 (264–469) 1,227 
a

Values of p from a G test for goodness-of-fit to the estimated log-series distribution; p < 0.05 indicates significant departure of the data from the log-series distribution.

b

Numbers assume fit to the estimated log-series distributions. CI, 95% confidence interval.

c

Calculated assuming that cells expressing Vβ13 or Vβ8 (S510), Vβ5 (S598), or Vβ8 (gp33) comprise 22 or 14% (7 ), 28% (our unpublished data), or 30% (22 ) of epitope S510-, S-598-, or gp33-specific CD8 T cells, respectively.

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