Antimicrobial and hemolytic activities of human sweat peptidesa
| . | Radial Diffusion Assay (μM) . | . | . | Liquid Assay (μM) . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | S. aureus mprF . | S. aureus (ATCC 25923) . | E. coli (O29) . | GAS (NZ131) . | C. albicans ATCC 14053 . | % Hemolysis . | ||||
| LL-37 | 32 | >64 | 64 | 8 | 20 | 9 | ||||
| RK-31 | 8 | 16 | 8 | 8 | 4 | 6 | ||||
| KS-30 | 8 | 16 | 8 | 4 | 2 | .23 | ||||
| KR-20 | 16 | >64 | >64 | 4 | 10 | 0 | ||||
| DCD | >64 | >64 | >64 | >64 | >32 | nd | ||||
| . | Radial Diffusion Assay (μM) . | . | . | Liquid Assay (μM) . | . | . | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| . | S. aureus mprF . | S. aureus (ATCC 25923) . | E. coli (O29) . | GAS (NZ131) . | C. albicans ATCC 14053 . | % Hemolysis . | ||||
| LL-37 | 32 | >64 | 64 | 8 | 20 | 9 | ||||
| RK-31 | 8 | 16 | 8 | 8 | 4 | 6 | ||||
| KS-30 | 8 | 16 | 8 | 4 | 2 | .23 | ||||
| KR-20 | 16 | >64 | >64 | 4 | 10 | 0 | ||||
| DCD | >64 | >64 | >64 | >64 | >32 | nd | ||||
Radial diffusion assay results represent minimal inhibitory concentrations determined for peptides against the indicated bacteria. Liquid assay results represent the minimal concentration required to kill group A S. aureus (GAS) or C. albicans. The percent hemolysis is shown for peptides at the following concentrations: LL-37 and KR-20, 100 μM; RK-31, 44 μM; KS-30, 88 μM. nd, not done.