Summary of tumor-reactive T cell persistence in melanoma patients after adoptive cell transfera
| Patient . | Clonotype . | Pre-PBL . | TIL . | PBL 1 wk . | PBL 2 wk . | PBL 4 wk . | PBL 8 wk . | Tumor 4 wk . | Tumor Reactivity . | Clinical Response . |
|---|---|---|---|---|---|---|---|---|---|---|
| 1803 | TRBV7-2 | 0 | 8 | 58 | 60 | 42 | 44 | N/A | Yes | PR |
| TRBV20-1 | 2 | 65 | 4 | 7 | 8 | 21 | N/A | Unknown | ||
| 2023 | TRBV24-1 | 0 | 82 | 79 | 3 | 3 | 0 | 11 | Yes | PR |
| TRBV29-1 | 4 | 1 | 3 | 5 | 8 | 2 | 1 | Unknown |
| Patient . | Clonotype . | Pre-PBL . | TIL . | PBL 1 wk . | PBL 2 wk . | PBL 4 wk . | PBL 8 wk . | Tumor 4 wk . | Tumor Reactivity . | Clinical Response . |
|---|---|---|---|---|---|---|---|---|---|---|
| 1803 | TRBV7-2 | 0 | 8 | 58 | 60 | 42 | 44 | N/A | Yes | PR |
| TRBV20-1 | 2 | 65 | 4 | 7 | 8 | 21 | N/A | Unknown | ||
| 2023 | TRBV24-1 | 0 | 82 | 79 | 3 | 3 | 0 | 11 | Yes | PR |
| TRBV29-1 | 4 | 1 | 3 | 5 | 8 | 2 | 1 | Unknown |
Pre-PBL was the PBL sample obtained prior to adoptive cell transfer, and the other PBL samples were obtained at different time points after treatment. N/A, not available; PR, partial response.