HCC patient characteristics
| Patient Code . | Age/Sex . | Number of Tumor Lesions, Size . | Histologya . | Serology . | HLA-A, -Bb . |
|---|---|---|---|---|---|
| LAU 669 | 70/male | Six lesions, diameters 18, 5.5, 2, 1.8, 1.6, and 0.8 cm; infiltration of neighbouring organs | Low differentiation; moderate lymphocytic infiltration | HBs negative, anti-HBc negative, HCV negative, anti-HCV negative | A*0201, A24(9), B62(15), Bx |
| LAU 674 | 68/male | Three lesions, largest lesion 3 × 2 × 2 cm | Moderate differentiation; slight lymphocytic inifiltration; liver cirrhosis. | HBs negative, anti-HBc negative, anti-HCV positive | A*0201c, A3, B35, B51(5) |
| LAU 698 | 75/male | Two lesions, diameters 5 and 3.5 cm | Moderate differentiation; slight lymphocytic infiltration | HBs negative, anti-HBc negative, HCV negative, anti-HCV negative | A1, A*0201, B7, B37 |
| LAU 748 | 81/female | One lesion, diameter 13 × 6 × 5 cm | Low differentiation; no lymphocytic infiltration | HBs negative, anti-HBc negative, anti-HCV negative | A*0201, A28, B18, B27 |
| LAU 766 | 70/male | Multiple lesions, diameters between 1 and 2 cm | Moderate differentiation; no lymphocytic infiltration; liver cirrhosis | HBs negative, anti-HBc negative, anti-HCV positive | A*0201, A*31d |
| LAU 812 | 68/female | One lesion, diameter 2 × 2 × 2 cm | Well differentiated; strong lymphocytic infiltration | HBs negative, anti-HBc negative, anti-HCV negative | A*0201, A3, B13, B62(15) |
| Patient Code . | Age/Sex . | Number of Tumor Lesions, Size . | Histologya . | Serology . | HLA-A, -Bb . |
|---|---|---|---|---|---|
| LAU 669 | 70/male | Six lesions, diameters 18, 5.5, 2, 1.8, 1.6, and 0.8 cm; infiltration of neighbouring organs | Low differentiation; moderate lymphocytic infiltration | HBs negative, anti-HBc negative, HCV negative, anti-HCV negative | A*0201, A24(9), B62(15), Bx |
| LAU 674 | 68/male | Three lesions, largest lesion 3 × 2 × 2 cm | Moderate differentiation; slight lymphocytic inifiltration; liver cirrhosis. | HBs negative, anti-HBc negative, anti-HCV positive | A*0201c, A3, B35, B51(5) |
| LAU 698 | 75/male | Two lesions, diameters 5 and 3.5 cm | Moderate differentiation; slight lymphocytic infiltration | HBs negative, anti-HBc negative, HCV negative, anti-HCV negative | A1, A*0201, B7, B37 |
| LAU 748 | 81/female | One lesion, diameter 13 × 6 × 5 cm | Low differentiation; no lymphocytic infiltration | HBs negative, anti-HBc negative, anti-HCV negative | A*0201, A28, B18, B27 |
| LAU 766 | 70/male | Multiple lesions, diameters between 1 and 2 cm | Moderate differentiation; no lymphocytic infiltration; liver cirrhosis | HBs negative, anti-HBc negative, anti-HCV positive | A*0201, A*31d |
| LAU 812 | 68/female | One lesion, diameter 2 × 2 × 2 cm | Well differentiated; strong lymphocytic infiltration | HBs negative, anti-HBc negative, anti-HCV negative | A*0201, A3, B13, B62(15) |
Tumor differentiation and cirrhosis was analyzed with H&E sections. Intratumoral T cell infiltration was analyzed with sections stained with CD3-specific Ab.
HLA typing for HLA-A,-B was done by serology, and for A2 subtypes with HLA allele-sequence-specific primers.
The rare alleles A*0259/60/64 cannot be excluded.
The rare heterozygous combinations A*0258/59/60/64 and A*3109 cannot be excluded.