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Table II.

Anti-virus Ab production in MMTV-infected chimeric I/LnJ IFN-γ-deficient recipient micea

Cells Removed from I/LnJ Splenocytes
NoneNKCD11bCD11cCD11c CD11bMHCIIBCD4CD8
8/16 7/15 5/11 4/8 6/7 17/33 4/6 0/11 5/9 
Cells Removed from I/LnJ Splenocytes
NoneNKCD11bCD11cCD11c CD11bMHCIIBCD4CD8
8/16 7/15 5/11 4/8 6/7 17/33 4/6 0/11 5/9 
a

Numbers in table body indicate number of mice producing anti-MMTV polyvalent Abs per total number of recipient mice. Splenic DNA isolated from all the recipient IFN-γ-deficient mice was subjected to semiquantitative IFN-γ-specific PCR to ensure that the mice were chimeric. All mice producing polyvalent Abs also secreted IgG2a-specific anti-virus Abs.

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