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Table I.

Age-related differences in airway tissue eosinophilia and goblet cell hyperplasia after primary (1°) and secondary (2°) RSV infectiona

1° InfectionShamuvRSVRSVuvRSVRSV
2° InfectionRSVRSV
Tissue eosinophils (MBP-positive cells/mm BM)      
 Age at 1° infection      
  <1 wk 3.5 ± 0.8 3.3 ± 0.9 6.8 ± 1.0b 2.2 ± 0.8 15.6 ± 3.8c 
  3 wk 0.7 ± 0.3 0.5 ± 0.3 2.1 ± 0.9 1.5 ± 0.6 0.5 ± 0.1 
  6 wk 0.6 ± 0.3  1.6 ± 0.4   
  8 wk 0.6 ± 0.2  1.3 ± 0.4   
Goblet cells (PAS-stained cells/mm BM)      
 Age at 1° infection      
  <1 wk 4.5 ± 1.2 5.0 ± 0.9 21.6 ± 3.0b 9.8 ± 3.3b 125.3 ± 15.8c 
  3 wk 1.3 ± 0.2 1.8 ± 0.5 13.3 ± 2.5b 12.3 ± 1.7b 10.0 ± 2.3c 
  6 wk 1.1 ± 0.2  11.0 ± 2.4b   
  8 wk 1.0 ± 0.3  10.4 ± 2.3b   
1° InfectionShamuvRSVRSVuvRSVRSV
2° InfectionRSVRSV
Tissue eosinophils (MBP-positive cells/mm BM)      
 Age at 1° infection      
  <1 wk 3.5 ± 0.8 3.3 ± 0.9 6.8 ± 1.0b 2.2 ± 0.8 15.6 ± 3.8c 
  3 wk 0.7 ± 0.3 0.5 ± 0.3 2.1 ± 0.9 1.5 ± 0.6 0.5 ± 0.1 
  6 wk 0.6 ± 0.3  1.6 ± 0.4   
  8 wk 0.6 ± 0.2  1.3 ± 0.4   
Goblet cells (PAS-stained cells/mm BM)      
 Age at 1° infection      
  <1 wk 4.5 ± 1.2 5.0 ± 0.9 21.6 ± 3.0b 9.8 ± 3.3b 125.3 ± 15.8c 
  3 wk 1.3 ± 0.2 1.8 ± 0.5 13.3 ± 2.5b 12.3 ± 1.7b 10.0 ± 2.3c 
  6 wk 1.1 ± 0.2  11.0 ± 2.4b   
  8 wk 1.0 ± 0.3  10.4 ± 2.3b   
a

Data are expressed as the mean number of cells (±SEM) detected in central airways. Data are normalized to the length of airway epithelium BM.

b

Significant difference compared with age-matched, sham-inoculated, control group (p < 0.05).

c

Significant difference compared with 1° RSV in mice infected at <1 wk of age (p < 0.05).

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