Inflammation scoresa
| . | WT . | CD14 KO . | TLR4 KO . | TLR2 KO . |
|---|---|---|---|---|
| 6 h | 9.6 ± 0.6 | 5.5 ± 0.9c | 4.9 ± 0.3c | 7.1 ± 0.7 |
| 24 h | 9.8 ± 0.6 | 7.2 ± 0.4 | 9.9 ± 0.9 | 8.1 ± 0.7 |
| 44 h | 8.9 ± 0.7 | 12.8 ± 1.3c | 10.6 ± 0.7 | 9.6 ± 1.1 |
| 10 days | 1.5 ± 0.3 | 8.1 ± 0.5c | 4.4 ± 0.5c | 3.1 ± 0.3b |
| . | WT . | CD14 KO . | TLR4 KO . | TLR2 KO . |
|---|---|---|---|---|
| 6 h | 9.6 ± 0.6 | 5.5 ± 0.9c | 4.9 ± 0.3c | 7.1 ± 0.7 |
| 24 h | 9.8 ± 0.6 | 7.2 ± 0.4 | 9.9 ± 0.9 | 8.1 ± 0.7 |
| 44 h | 8.9 ± 0.7 | 12.8 ± 1.3c | 10.6 ± 0.7 | 9.6 ± 1.1 |
| 10 days | 1.5 ± 0.3 | 8.1 ± 0.5c | 4.4 ± 0.5c | 3.1 ± 0.3b |
Groups of five to nine mice were i.n. inoculated with 1 × 107 CFU of NTHi. After 6, 24, and 44 h as well as 10 days, inflammation was scored on H&E-stained slides (for details, see Materials and Methods). Data are expressed as mean ± SEM.
, p < 0.05;
, p < 0.01 vs WT control.