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Table I.

Inflammation scoresa

WTCD14 KOTLR4 KOTLR2 KO
6 h 9.6 ± 0.6 5.5 ± 0.9c 4.9 ± 0.3c 7.1 ± 0.7 
24 h 9.8 ± 0.6 7.2 ± 0.4 9.9 ± 0.9 8.1 ± 0.7 
44 h 8.9 ± 0.7 12.8 ± 1.3c 10.6 ± 0.7 9.6 ± 1.1 
10 days 1.5 ± 0.3 8.1 ± 0.5c 4.4 ± 0.5c 3.1 ± 0.3b 
WTCD14 KOTLR4 KOTLR2 KO
6 h 9.6 ± 0.6 5.5 ± 0.9c 4.9 ± 0.3c 7.1 ± 0.7 
24 h 9.8 ± 0.6 7.2 ± 0.4 9.9 ± 0.9 8.1 ± 0.7 
44 h 8.9 ± 0.7 12.8 ± 1.3c 10.6 ± 0.7 9.6 ± 1.1 
10 days 1.5 ± 0.3 8.1 ± 0.5c 4.4 ± 0.5c 3.1 ± 0.3b 
a

Groups of five to nine mice were i.n. inoculated with 1 × 107 CFU of NTHi. After 6, 24, and 44 h as well as 10 days, inflammation was scored on H&E-stained slides (for details, see Materials and Methods). Data are expressed as mean ± SEM.

b

, p < 0.05;

c

, p < 0.01 vs WT control.

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