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Table I.

Genes differentially expressed in M1 vs M2 macrophagesa

Gene NameGene SymbolM1M2M1:M2 Ratio
Membrane receptors     
 CCR7 CCR7 5,893 55 107 
 Interleukin 2 receptor α chain IL2RA 4,062 181 22 
 Interleukin 15 receptor α chain IL15RA 2,867 178 16 
 Interleukin 7 receptor IL7R 1,553 115 13 
 G protein-coupled receptor 86 GPR86 342 1,852 −5 
 Purinergic receptor P2Y5 P2RY5 284 2,610 −9 
 Transforming growth factor β receptor II TGFBR2 218 2,274 −10 
 Histamine receptor H1 HRH1 182 1,918 −11 
 Toll-like receptor 5 TLR5 76 915 −12 
 C-type lectin receptor DCL-1 DCL-1 179 2,265 −13 
 Macrophage scavenger receptor 1 MSR1 7 107 −14 
 CXCR4 CXCR4 168 2,678 −16 
 C-type lectin superfamily member 12 DECTIN1 130 2,520 −19 
 G protein-coupled receptor 105 P2RY14 16 416 −25 
 CD209 DCSIGN 315 8,355 −27 
 C-type lectin superfamily member 13 CLECSF13 93 2,946 −32 
 Membrane-spanning 4-domains, subfamily A, member 6A MS4A6A 247 8,064 −33 
 CD36 CD36 73 2,713 −37 
 Membrane-spanning 4-domains, subfamily A, member 4 MS4A4A 16 688 −43 
 Mannose receptor C type 1 MRC1 173 7,343 −43 
Cytokines and chemokines     
 CXCL11 CXCL11 4,084 19 212 
 CCL19 CCL19 13,338 103 130 
 CXCL10 CXCL10 11,659 199 59 
 CXCL9 CXCL9 15,121 260 58 
 Tumor necrosis factor ligand superfamily, member 2 TNF 977 47 21 
 CCL5 CCL5 6,468 334 19 
 CCL15 CCL15 2,402 164 15 
 Interleukin 12B IL12B 198 20 10 
 Interleukin 15 IL15 259 29 9 
 Tumor necrosis factor ligand superfamily, member 10 TRAIL 2,354 343 7 
 Interleukin 6 IL6 591 83 7 
 CCL20 CCL20 316 47 7 
 Visfatin PBEF1 2,297 446 5 
 Endothelial cell growth factor 1 ECGF1 1,636 370 4 
 Insulin-like growth factor 1 IGF1 217 1,212 −6 
 CCL23 CCL23 270 3,542 −13 
 CCL18 CCL18 290 5,457 −19 
 CCL13 CCL13 133 5,028 −38 
Apoptosis-related genes     
 BCL2-related protein A1 BCL2A1 4,018 117 34 
 Tumor necrosis factor receptor superfamily, member 6 FAS 2,243 156 14 
 Baculoviral IAP repeat-containing 3 BIRC3 1,318 162 8 
 Growth arrest and DNA-damage-inducible, γ GADD45G 682 144 5 
 XIAP associated factor-1 HSXIAPAF1 1,928 445 4 
Solute carriers     
 Solute carrier family 7, member 5 SLC7A5 2,509 259 10 
 Solute carrier family 21, member 15 SLC21A15 371 52 7 
 Solute carrier family 2, member 6 SLC2A6 2,981 513 6 
 Solute carrier family 31, member 2 SLC31A2 4,022 850 5 
 Solute carrier family 2, member 9 SLC21A9 338 2,476 −7 
 Solute carrier family 4, member 7 SLC4A7 43 388 −9 
 Solute carrier family 38, member 6 SLC38A6 99 2,370 −24 
Enzymes     
 Indoleamine-pyrrole 2,3 dioxygenase INDO 16,605 142 117 
 Phospholipase A1 member A PLA1A 1,854 55 33 
 2′–5′-oligoadenylate synthetase-like OASL 3,272 237 14 
 Chitinase 3-like 2 CHI3L2 1,078 89 12 
 Hydroxysteroid (11-β) dehydrogenase 1 HSD11B1 4,066 476 9 
 Adenylate kinase 3 AK3 702 103 7 
 Sphingosine kinase 1 SPHK1 1,974 324 6 
 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 PFKFB3 2,983 509 6 
 Proteasome activator subunit 2 PSME2 10,918 1,789 6 
 Phosphofructokinase PFKP 1,618 310 5 
 Proteasome subunit β type 9 PSMB9 3,888 817 5 
 Proteasome subunit α type 2 PSMA2 4,957 1,199 4 
 2′–5′-oligoadenylate synthetase 2 OAS2 944 261 4 
 Cathepsin C CTSC 3,161 13,800 −4 
 Hexosaminidase B HEXB 1,582 6,809 −4 
 Lipase A cholesterol esterase LIPA 2,252 9,772 −4 
Gene NameGene SymbolM1M2M1:M2 Ratio
Membrane receptors     
 CCR7 CCR7 5,893 55 107 
 Interleukin 2 receptor α chain IL2RA 4,062 181 22 
 Interleukin 15 receptor α chain IL15RA 2,867 178 16 
 Interleukin 7 receptor IL7R 1,553 115 13 
 G protein-coupled receptor 86 GPR86 342 1,852 −5 
 Purinergic receptor P2Y5 P2RY5 284 2,610 −9 
 Transforming growth factor β receptor II TGFBR2 218 2,274 −10 
 Histamine receptor H1 HRH1 182 1,918 −11 
 Toll-like receptor 5 TLR5 76 915 −12 
 C-type lectin receptor DCL-1 DCL-1 179 2,265 −13 
 Macrophage scavenger receptor 1 MSR1 7 107 −14 
 CXCR4 CXCR4 168 2,678 −16 
 C-type lectin superfamily member 12 DECTIN1 130 2,520 −19 
 G protein-coupled receptor 105 P2RY14 16 416 −25 
 CD209 DCSIGN 315 8,355 −27 
 C-type lectin superfamily member 13 CLECSF13 93 2,946 −32 
 Membrane-spanning 4-domains, subfamily A, member 6A MS4A6A 247 8,064 −33 
 CD36 CD36 73 2,713 −37 
 Membrane-spanning 4-domains, subfamily A, member 4 MS4A4A 16 688 −43 
 Mannose receptor C type 1 MRC1 173 7,343 −43 
Cytokines and chemokines     
 CXCL11 CXCL11 4,084 19 212 
 CCL19 CCL19 13,338 103 130 
 CXCL10 CXCL10 11,659 199 59 
 CXCL9 CXCL9 15,121 260 58 
 Tumor necrosis factor ligand superfamily, member 2 TNF 977 47 21 
 CCL5 CCL5 6,468 334 19 
 CCL15 CCL15 2,402 164 15 
 Interleukin 12B IL12B 198 20 10 
 Interleukin 15 IL15 259 29 9 
 Tumor necrosis factor ligand superfamily, member 10 TRAIL 2,354 343 7 
 Interleukin 6 IL6 591 83 7 
 CCL20 CCL20 316 47 7 
 Visfatin PBEF1 2,297 446 5 
 Endothelial cell growth factor 1 ECGF1 1,636 370 4 
 Insulin-like growth factor 1 IGF1 217 1,212 −6 
 CCL23 CCL23 270 3,542 −13 
 CCL18 CCL18 290 5,457 −19 
 CCL13 CCL13 133 5,028 −38 
Apoptosis-related genes     
 BCL2-related protein A1 BCL2A1 4,018 117 34 
 Tumor necrosis factor receptor superfamily, member 6 FAS 2,243 156 14 
 Baculoviral IAP repeat-containing 3 BIRC3 1,318 162 8 
 Growth arrest and DNA-damage-inducible, γ GADD45G 682 144 5 
 XIAP associated factor-1 HSXIAPAF1 1,928 445 4 
Solute carriers     
 Solute carrier family 7, member 5 SLC7A5 2,509 259 10 
 Solute carrier family 21, member 15 SLC21A15 371 52 7 
 Solute carrier family 2, member 6 SLC2A6 2,981 513 6 
 Solute carrier family 31, member 2 SLC31A2 4,022 850 5 
 Solute carrier family 2, member 9 SLC21A9 338 2,476 −7 
 Solute carrier family 4, member 7 SLC4A7 43 388 −9 
 Solute carrier family 38, member 6 SLC38A6 99 2,370 −24 
Enzymes     
 Indoleamine-pyrrole 2,3 dioxygenase INDO 16,605 142 117 
 Phospholipase A1 member A PLA1A 1,854 55 33 
 2′–5′-oligoadenylate synthetase-like OASL 3,272 237 14 
 Chitinase 3-like 2 CHI3L2 1,078 89 12 
 Hydroxysteroid (11-β) dehydrogenase 1 HSD11B1 4,066 476 9 
 Adenylate kinase 3 AK3 702 103 7 
 Sphingosine kinase 1 SPHK1 1,974 324 6 
 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 PFKFB3 2,983 509 6 
 Proteasome activator subunit 2 PSME2 10,918 1,789 6 
 Phosphofructokinase PFKP 1,618 310 5 
 Proteasome subunit β type 9 PSMB9 3,888 817 5 
 Proteasome subunit α type 2 PSMA2 4,957 1,199 4 
 2′–5′-oligoadenylate synthetase 2 OAS2 944 261 4 
 Cathepsin C CTSC 3,161 13,800 −4 
 Hexosaminidase B HEXB 1,582 6,809 −4 
 Lipase A cholesterol esterase LIPA 2,252 9,772 −4 

(Table continues)

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