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Table I.

Consecutive events during IgE-mediated enhancement of immune responses

Time after First Immunization with IgE/AgEffect on the Immune ResponseFig./Ref.
5 min Ag found on peripheral B cells Fig. 1 B 
30 min Ag in splenic B cell follicles on FO B cells Fig. 2  
6–12 h Ag-specific CD4+ T cells localize close to the T-B border in spleen Fig. 3, D and E 
3 days Massive proliferation of Ag-specific CD4+ T cells in the T cell zone Fig. 3 F/Ref. 19  
7–14 days Increase in size and number of GCs Fig. 4, A and C 
7–123 days Enhanced first Ab response Fig. 4 B/Refs. 14 15 16 17 18 19 and 54 ) 
138 days Enhanced recall response 14 days after boost with Ag alone Ref. 15  
Time after First Immunization with IgE/AgEffect on the Immune ResponseFig./Ref.
5 min Ag found on peripheral B cells Fig. 1 B 
30 min Ag in splenic B cell follicles on FO B cells Fig. 2  
6–12 h Ag-specific CD4+ T cells localize close to the T-B border in spleen Fig. 3, D and E 
3 days Massive proliferation of Ag-specific CD4+ T cells in the T cell zone Fig. 3 F/Ref. 19  
7–14 days Increase in size and number of GCs Fig. 4, A and C 
7–123 days Enhanced first Ab response Fig. 4 B/Refs. 14 15 16 17 18 19 and 54 ) 
138 days Enhanced recall response 14 days after boost with Ag alone Ref. 15  
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