Consecutive events during IgE-mediated enhancement of immune responses
| Time after First Immunization with IgE/Ag . | Effect on the Immune Response . | Fig./Ref. . |
|---|---|---|
| 5 min | Ag found on peripheral B cells | Fig. 1 B |
| 30 min | Ag in splenic B cell follicles on FO B cells | Fig. 2 |
| 6–12 h | Ag-specific CD4+ T cells localize close to the T-B border in spleen | Fig. 3, D and E |
| 3 days | Massive proliferation of Ag-specific CD4+ T cells in the T cell zone | Fig. 3 F/Ref. 19 |
| 7–14 days | Increase in size and number of GCs | Fig. 4, A and C |
| 7–123 days | Enhanced first Ab response | Fig. 4 B/Refs. 14 15 16 17 18 19 and 54 ) |
| 138 days | Enhanced recall response 14 days after boost with Ag alone | Ref. 15 |
| Time after First Immunization with IgE/Ag . | Effect on the Immune Response . | Fig./Ref. . |
|---|---|---|
| 5 min | Ag found on peripheral B cells | Fig. 1 B |
| 30 min | Ag in splenic B cell follicles on FO B cells | Fig. 2 |
| 6–12 h | Ag-specific CD4+ T cells localize close to the T-B border in spleen | Fig. 3, D and E |
| 3 days | Massive proliferation of Ag-specific CD4+ T cells in the T cell zone | Fig. 3 F/Ref. 19 |
| 7–14 days | Increase in size and number of GCs | Fig. 4, A and C |
| 7–123 days | Enhanced first Ab response | Fig. 4 B/Refs. 14 15 16 17 18 19 and 54 ) |
| 138 days | Enhanced recall response 14 days after boost with Ag alone | Ref. 15 |