American Association of Immunologists

Table I.

Genes transcriptionally induced in joint tissue of BL206-infected C3H/HeJ mice 2 wk postinfection

Function	Gene Name	FC^a	p Value	Function	Gene Name	FC^a	p Value
Cytokines/chemokines	CXCL13	108.1	<0.0001	Apoptosis	SARP-1	2.4	0.0002
	IL-1β	41.8	<0.0001	Cell adhesion	Integrin-β2	4.2	<0.0001
	CCL2/MCP-1	14.9	<0.0001		Integrin-α4	3.7	0.0093
	CXCL6	7.4	<0.0001		Integrin-αL	3.4	<0.0001
	CXCL9	6.8	<0.0001		ICAM-1	2.0	0.0011
	CCL7/MCP-3	2.8	<0.0001	Cell proliferation	TP1	2.6	<0.0001
	CCL6	2.6	0.0005	Cytokine suppression	CIS3/SOCS3	2.1	0.0033
	CCL9/MIP-1γ	2.5	<0.0001	Growth/development	TNFRSF1B	5.8	<0.0001
	CCL19/MIP-3β	2.4	0.0017		Cerberus	3.0	0.0010
	CXCL14/BRAK	2.3	<0.0001		c-fos	2.2	<0.0001
	CXCL15/lungkine	2.0	0.0002		LTBP-2	2.1	0.0093
	CCL3/MIP-1α	2.0	0.0058	Invasion/migration	MMP-3	8.8	<0.0001
Receptors/antagonists	CCR-9	158.1	0.0020		TIMP-1	3.4	<0.0001
	IL-1R antagonist	26.1	<0.0001	Lymphocyte activation	CD45	2.9	0.0002
	CCR-5	17.8	<0.0001		MD-1	2.7	<0.0001
	IL-12Rβ1	10.2	0.0101	Proinflammatory	Cox-2	7.2	<0.0001
	IL-18R	4.5	0.0083		Stat1	6.5	<0.0001
	IL-10Rα	3.7	<0.0001	Caspase-1	2.7	0.0001
	IL-2Rγ	2.9	0.0001		Stat4	2.1	0.0015
	CCR-2	2.9	<0.0001	TNF superfamily	TNFSF6/FasL	2.7	<0.0001
	IL-13Rα1	2.5	<0.0001		TNFRSF10B	2.2	<0.0001
	IL-8R	2.1	0.0054
	IL-18R AcP	2.1	0.0026
	IL-1RI	2.0	0.0025

Function	Gene Name	FC^a	p Value	Function	Gene Name	FC^a	p Value
Cytokines/chemokines	CXCL13	108.1	<0.0001	Apoptosis	SARP-1	2.4	0.0002
	IL-1β	41.8	<0.0001	Cell adhesion	Integrin-β2	4.2	<0.0001
	CCL2/MCP-1	14.9	<0.0001		Integrin-α4	3.7	0.0093
	CXCL6	7.4	<0.0001		Integrin-αL	3.4	<0.0001
	CXCL9	6.8	<0.0001		ICAM-1	2.0	0.0011
	CCL7/MCP-3	2.8	<0.0001	Cell proliferation	TP1	2.6	<0.0001
	CCL6	2.6	0.0005	Cytokine suppression	CIS3/SOCS3	2.1	0.0033
	CCL9/MIP-1γ	2.5	<0.0001	Growth/development	TNFRSF1B	5.8	<0.0001
	CCL19/MIP-3β	2.4	0.0017		Cerberus	3.0	0.0010
	CXCL14/BRAK	2.3	<0.0001		c-fos	2.2	<0.0001
	CXCL15/lungkine	2.0	0.0002		LTBP-2	2.1	0.0093
	CCL3/MIP-1α	2.0	0.0058	Invasion/migration	MMP-3	8.8	<0.0001
Receptors/antagonists	CCR-9	158.1	0.0020		TIMP-1	3.4	<0.0001
	IL-1R antagonist	26.1	<0.0001	Lymphocyte activation	CD45	2.9	0.0002
	CCR-5	17.8	<0.0001		MD-1	2.7	<0.0001
	IL-12Rβ1	10.2	0.0101	Proinflammatory	Cox-2	7.2	<0.0001
	IL-18R	4.5	0.0083		Stat1	6.5	<0.0001
	IL-10Rα	3.7	<0.0001	Caspase-1	2.7	0.0001
	IL-2Rγ	2.9	0.0001		Stat4	2.1	0.0015
	CCR-2	2.9	<0.0001	TNF superfamily	TNFSF6/FasL	2.7	<0.0001
	IL-13Rα1	2.5	<0.0001		TNFRSF10B	2.2	<0.0001
	IL-8R	2.1	0.0054
	IL-18R AcP	2.1	0.0026
	IL-1RI	2.0	0.0025

FC indicates fold change relative to uninfected control.