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Table IV.

IC50 values determined from real-time PCR results after the ERB-041, WAY-202196, WAY-214156, or PPT treatmenta

IC50 ERαIC50 ERβIC50 ERα/ERβ
TNF-α    
 ERB-041 2.57 E-08 
 WAY-214156 3.60 E-04 1.60 E-08 2.25 E+04 
 WAY-202196 6.10 E-07 1.50 E-08 4.07 E+01 
 PPT 4.30 E-09 4.80 E-05 8.96 E-05 
CSF2    
 ERB-041 1.58 E-08 
 WAY-214156 1.60 E-07 6.70 E-09 2.39 E+01 
 WAY-202196 3.50 E-08 2.10 E-10 1.67 E+02 
 PPT 1.90 E-10 1.40 E-04 1.36 E-06 
IC50 ERαIC50 ERβIC50 ERα/ERβ
TNF-α    
 ERB-041 2.57 E-08 
 WAY-214156 3.60 E-04 1.60 E-08 2.25 E+04 
 WAY-202196 6.10 E-07 1.50 E-08 4.07 E+01 
 PPT 4.30 E-09 4.80 E-05 8.96 E-05 
CSF2    
 ERB-041 1.58 E-08 
 WAY-214156 1.60 E-07 6.70 E-09 2.39 E+01 
 WAY-202196 3.50 E-08 2.10 E-10 1.67 E+02 
 PPT 1.90 E-10 1.40 E-04 1.36 E-06 
a

U2OS-ERβ and U2OS-ERα were treated with increasing concentrations of the drugs as shown in Fig. 2. Analyses were done using the Prism curve-fitting program.

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