The adoptive transfer of CD8 TCM (CD62Lhigh) cells protects relB−/− BMC injected with peptide-pulsed DCsa
| . | Transfer of CD62Lhigh T cells (1 × 106/mouse) . | DC Reconstitutionb . | Virus Challenge i.n. (4 × 106 PFU/ml) . | Survivalc . |
|---|---|---|---|---|
| C57BL/6 BMC | + | − | + | 4/4 |
| relB BMC | + | + | + | 5/5 |
| C57BL/6 | + | − | + | 0/4 |
| . | Transfer of CD62Lhigh T cells (1 × 106/mouse) . | DC Reconstitutionb . | Virus Challenge i.n. (4 × 106 PFU/ml) . | Survivalc . |
|---|---|---|---|---|
| C57BL/6 BMC | + | − | + | 4/4 |
| relB BMC | + | + | + | 5/5 |
| C57BL/6 | + | − | + | 0/4 |
Mice were adoptively transferred with 106 CD62Lhigh CD8 T cells from immune C57Bl/6 mice.
BM-derived C57BL/6 DCs pulsed with NP366 peptide were injected 24 h after adoptive transfer of memory CD8 T cells and were allowed to park in vivo 10 days prior to virus challenge.
Survival was recorded over a period of 3 wk.