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Table III.

The adoptive transfer of CD8 TCM (CD62Lhigh) cells protects relB−/− BMC injected with peptide-pulsed DCsa

Transfer of CD62Lhigh T cells (1 × 106/mouse)DC ReconstitutionbVirus Challenge i.n. (4 × 106 PFU/ml)Survivalc
C57BL/6 BMC + − + 4/4 
relB BMC + + 5/5 
C57BL/6 + − + 0/4 
Transfer of CD62Lhigh T cells (1 × 106/mouse)DC ReconstitutionbVirus Challenge i.n. (4 × 106 PFU/ml)Survivalc
C57BL/6 BMC + − + 4/4 
relB BMC + + 5/5 
C57BL/6 + − + 0/4 
a

Mice were adoptively transferred with 106 CD62Lhigh CD8 T cells from immune C57Bl/6 mice.

b

BM-derived C57BL/6 DCs pulsed with NP366 peptide were injected 24 h after adoptive transfer of memory CD8 T cells and were allowed to park in vivo 10 days prior to virus challenge.

c

Survival was recorded over a period of 3 wk.

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