Important, unresolved areas of hydatid immunology that may inform improved vaccine design
| Required Tasks . |
|---|
| Precise identification of the Ig isotypes involved in protective immunity |
| Define the role of T cells as effectors of protective immunity and their regulation |
| Unravel the relationship between T cell and B cell responses in protective immunity |
| Characterize memory B and T cell recognition of protective Ags, including the EG95 vaccine |
| Determine the role(s) of Ab-dependent cell-mediated immune effector mechanisms such as the involvement of neutrophils and the eosinophil/IgE/mast cell axis and neutrophils with Ab in the killing of the infective larval stage (the oncosphere) contained within the egg |
| Evaluate cellular inflammatory responses/cell-mediated immunity, the generation of associated cytokine/chemokines, and the role of regulatory T cells, neutrophils, macrophages, eosinophils, fibrocytes, and NK cells in the early stages of infection |
| Determine the involvement of Ab-dependent, complement-mediated lysis (by the classical or alternative pathway) and the role of neutrophils in the immune killing of oncospheres in vivo |
| Required Tasks . |
|---|
| Precise identification of the Ig isotypes involved in protective immunity |
| Define the role of T cells as effectors of protective immunity and their regulation |
| Unravel the relationship between T cell and B cell responses in protective immunity |
| Characterize memory B and T cell recognition of protective Ags, including the EG95 vaccine |
| Determine the role(s) of Ab-dependent cell-mediated immune effector mechanisms such as the involvement of neutrophils and the eosinophil/IgE/mast cell axis and neutrophils with Ab in the killing of the infective larval stage (the oncosphere) contained within the egg |
| Evaluate cellular inflammatory responses/cell-mediated immunity, the generation of associated cytokine/chemokines, and the role of regulatory T cells, neutrophils, macrophages, eosinophils, fibrocytes, and NK cells in the early stages of infection |
| Determine the involvement of Ab-dependent, complement-mediated lysis (by the classical or alternative pathway) and the role of neutrophils in the immune killing of oncospheres in vivo |