Affinities of FcγRI, FcγRIIB, FcγRIII, and FcγRIV for 34-3C IgG1, IgG2b, and their mutantsa
| mAb . | FcγRI . | FcγRIIB . | FcγRIII . | FcγRIV . |
|---|---|---|---|---|
| IgG1 WT | NB | 1.2 × 106 | 2.1 × 105 | NB |
| IgG1[233–235] | NB | 1.7 × 106 | 1.3 × 106 | 1.0 × 106 |
| IgG2b WT | NB | 1.1 × 106 | 6.4 × 105 | 1.6 × 107 |
| IgG2bΔ233–235 | NB | 7.0 × 104 | 6.0 × 104 | <104 |
| IgG2a | 3.9 × 107 | 5.6 × 105 | 5.6 × 105 | 1.4 × 107 |
| mAb . | FcγRI . | FcγRIIB . | FcγRIII . | FcγRIV . |
|---|---|---|---|---|
| IgG1 WT | NB | 1.2 × 106 | 2.1 × 105 | NB |
| IgG1[233–235] | NB | 1.7 × 106 | 1.3 × 106 | 1.0 × 106 |
| IgG2b WT | NB | 1.1 × 106 | 6.4 × 105 | 1.6 × 107 |
| IgG2bΔ233–235 | NB | 7.0 × 104 | 6.0 × 104 | <104 |
| IgG2a | 3.9 × 107 | 5.6 × 105 | 5.6 × 105 | 1.4 × 107 |
Results are expressed as Ka (M−1). NB, No binding.