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Table I.

Affinities of FcγRI, FcγRIIB, FcγRIII, and FcγRIV for 34-3C IgG1, IgG2b, and their mutantsa

mAbFcγRIFcγRIIBFcγRIIIFcγRIV
IgG1 WT NB 1.2 × 106 2.1 × 105 NB 
IgG1[233–235] NB 1.7 × 106 1.3 × 106 1.0 × 106 
IgG2b WT NB 1.1 × 106 6.4 × 105 1.6 × 107 
IgG2bΔ233–235 NB 7.0 × 104 6.0 × 104 <104 
IgG2a 3.9 × 107 5.6 × 105 5.6 × 105 1.4 × 107 
mAbFcγRIFcγRIIBFcγRIIIFcγRIV
IgG1 WT NB 1.2 × 106 2.1 × 105 NB 
IgG1[233–235] NB 1.7 × 106 1.3 × 106 1.0 × 106 
IgG2b WT NB 1.1 × 106 6.4 × 105 1.6 × 107 
IgG2bΔ233–235 NB 7.0 × 104 6.0 × 104 <104 
IgG2a 3.9 × 107 5.6 × 105 5.6 × 105 1.4 × 107 
a

Results are expressed as Ka (M−1). NB, No binding.

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