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Table I.

Absolute numbers of total splenocytes and splenic T cell subsets

Treatmenta Absolute Numbersb (×106 ± SD)
TotalCD4+CD49b+CD4+CD49bCD4+CD8+CD49b+CD8+CD49bCD8+
Naïve 40.0 ± 1.72 7.57 ± 0.72 0.71 ± 0.18 6.86 ± 0.89 3.71 ± 0.28 0.35 ± 0.01 3.36 ± 0.28 
AGN2a/CD80 42.6 ± 2.55 7.78 ± 0.69 0.53 ± 0.02 7.25 ± 0.67 3.86 ± 0.29 0.50 ± 0.08 3.35 ± 0.21 
AGN2a/CD137L 42.9 ± 3.44 8.31 ± 1.23 0.75 ± 0.34 7.56 ± 1.58 3.87 ± 0.51 0.46 ± 0.06 3.42 ± 0.49 
AGN2a/DP 44.7 ± 1.97 7.67 ± 0.11 0.69 ± 0.08 6.98 ± 0.08 5.92 ± 0.53c 2.37 ± 0.23d 3.55 ± 0.32 
Treatmenta Absolute Numbersb (×106 ± SD)
TotalCD4+CD49b+CD4+CD49bCD4+CD8+CD49b+CD8+CD49bCD8+
Naïve 40.0 ± 1.72 7.57 ± 0.72 0.71 ± 0.18 6.86 ± 0.89 3.71 ± 0.28 0.35 ± 0.01 3.36 ± 0.28 
AGN2a/CD80 42.6 ± 2.55 7.78 ± 0.69 0.53 ± 0.02 7.25 ± 0.67 3.86 ± 0.29 0.50 ± 0.08 3.35 ± 0.21 
AGN2a/CD137L 42.9 ± 3.44 8.31 ± 1.23 0.75 ± 0.34 7.56 ± 1.58 3.87 ± 0.51 0.46 ± 0.06 3.42 ± 0.49 
AGN2a/DP 44.7 ± 1.97 7.67 ± 0.11 0.69 ± 0.08 6.98 ± 0.08 5.92 ± 0.53c 2.37 ± 0.23d 3.55 ± 0.32 
a

Groups of mice were vaccinated s.c. with the indicated tumor cells as indicated in Fig. 1 and spleens were harvested 5 days after the second vaccination. A group of nonvaccinated controls (naive) was also included. Splenocytes were stained with the indicated markers and absolute numbers of different cell subsets were calculated.

b

The data were determined from one of two replicate experiments (n = 3 mice/group).

c

p < 0.05 vs the other three groups.

d

p < 0.005 vs the other three groups.

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