Comparative analysis of C3b/C4b mouse and human regulatory proteins
| Gene . | Protein . | Size (Da) . | Function . | Cell Type Expression . |
|---|---|---|---|---|
| Mouse | ||||
| Crry | Crry | 65,000 | Receptor: decay C convertase and cofactor for C3 cleavage | All cells including erythrocytes |
| Cr2 | CR2 | 145,000 | Receptor: C3d, C3dg, C3d-bound complexes | B cells and FDC |
| Cr2 | CR1 | 200,000 | Receptor: C3b, C4b-bound complexes and cofactor for C3 cleavage | B cells and FDC |
| Daf 1,2 | Daf 1,2 | 70,000 | Receptor: decay C convertase | All cells including erythrocytes |
| CD46 | Mcp | 60,000 | Receptor: sperm acrosome reaction | Testis |
| Cfh | Factor H | 150,000 | Serum: cofactor for C3 cleavage and decay C3 convertase | Hepatocytes (serum) |
| C4BP | C4bp | 570,000 | Serum: cofactor C4 cleavage | Hepatocytes (serum) |
| Human | ||||
| CR1 | CR1 | 180–280,000 | Receptor: C3b, C4b-bound complexes, cofactor for C3 cleavage and decay C convertase | T,B cells, phagocytes FDC, erythrocytes, glomerular podocytes |
| CR2 | CR2 | 145,000 | Receptor: C3d, C3dg, C3d-bound complexes | B cells and FDC |
| DAF | DAF | 70,000 | Receptor: decay C convertase | All cells including erythrocytes |
| MCP | MCP | 60,000 | Receptor: cofactor, C3 cleavage | Nucleated cells |
| CFH | Factor H | 150,000 | Serum: cofactor C3 cleavage, C3 convertase decay | Hepatocytes (serum) |
| C4BP | C4BP | 570,000 | Serum: cofactor C4 cleavage | Hepatocytes (serum) |
| Gene . | Protein . | Size (Da) . | Function . | Cell Type Expression . |
|---|---|---|---|---|
| Mouse | ||||
| Crry | Crry | 65,000 | Receptor: decay C convertase and cofactor for C3 cleavage | All cells including erythrocytes |
| Cr2 | CR2 | 145,000 | Receptor: C3d, C3dg, C3d-bound complexes | B cells and FDC |
| Cr2 | CR1 | 200,000 | Receptor: C3b, C4b-bound complexes and cofactor for C3 cleavage | B cells and FDC |
| Daf 1,2 | Daf 1,2 | 70,000 | Receptor: decay C convertase | All cells including erythrocytes |
| CD46 | Mcp | 60,000 | Receptor: sperm acrosome reaction | Testis |
| Cfh | Factor H | 150,000 | Serum: cofactor for C3 cleavage and decay C3 convertase | Hepatocytes (serum) |
| C4BP | C4bp | 570,000 | Serum: cofactor C4 cleavage | Hepatocytes (serum) |
| Human | ||||
| CR1 | CR1 | 180–280,000 | Receptor: C3b, C4b-bound complexes, cofactor for C3 cleavage and decay C convertase | T,B cells, phagocytes FDC, erythrocytes, glomerular podocytes |
| CR2 | CR2 | 145,000 | Receptor: C3d, C3dg, C3d-bound complexes | B cells and FDC |
| DAF | DAF | 70,000 | Receptor: decay C convertase | All cells including erythrocytes |
| MCP | MCP | 60,000 | Receptor: cofactor, C3 cleavage | Nucleated cells |
| CFH | Factor H | 150,000 | Serum: cofactor C3 cleavage, C3 convertase decay | Hepatocytes (serum) |
| C4BP | C4BP | 570,000 | Serum: cofactor C4 cleavage | Hepatocytes (serum) |