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Table IV.

Genes preferentially up-regulated by LPSa

GeneDescriptionFold InductionRatiob
TREMLPSDual
IL23A IL 23, α subunit (IL-23p19) 1.1 54.4 18.4 76.4 
TNIP3 TNFAIP3 interacting protein 3 (ABIN-3) 1.2 124.2 14.3 64.7 
CSF3 Colony stimulating factor 3 (G-CSF) 1.3 45.2 36.4 54.4 
IL12B IL 12, β subunit (IL-12p40) −1.1 31.8 4.0 31.1 
EBI3 EBV induced gene 3 (IL-27, β subunit) −1.9 10.5 2.8 20.9 
CCL23 Chemokine (MIP-3) −2.0 5.6 1.5 16.8 
PTTG1IP Pituitary tumor-transforming 1 interacting protein −1.6 8.0 2.9 15.2 
TIFA TRAF-interacting with a Forkhead-associated domain −2.3 6.7 2.7 14.8 
IL1F9 IL 1 family, 9 (ε) 2.7 34.3 23.5 13.9 
KCNJ2 K+ inwardly-rectifying channel, J2 −2.3 5.7 1.6 13.0 
BF B-factor; complement factor B (CFB) 1.2 13.0 4.7 12.6 
GBP3 Guanylate binding protein 3 −2.2 4.9 2.3 10.7 
CIAS1 Cold autoinflammatory syndrome 1 (NLRP3/cryopyrin) −1.2 7.6 5.1 9.8 
CDC2 Cell division cycle 2, G1 to S and G2 to M 1.6 12.8 6.5 9.4 
TPRT Trans-Prenyltransferase (PDSS1) −1.0 9.5 5.7 9.2 
CXCL1 Chemokine (GRO-α) 2.6 21.7 9.2 9.1 
TSLP Thymic stromal lymphopoietin (cytokine) 3.6 30.8 37.6 9.1 
NFKBIZ NF-κB gene enhancer in B-cells inhibitor, ζ −1.8 4.4 3.4 8.2 
PDCD1LG1 Programmed cell death 1 ligand 1 (B7-H1) 2.0 17.6 6.6 7.7 
ZBTB10 Zn2+ finger and BTB domain containing 10 −1.1 6.4 4.1 7.6 
LAMP3 Lysosomal-associated membrane protein 3 (DC-LAMP) 1.1 10.5 3.8 7.2 
MCOLN2 Mucolipin 2; cation channel −1.3 5.1 2.0 7.2 
IL15RA IL 15 receptor, α −1.4 4.2 2.2 6.6 
ICAM4 Intercellular adhesion molecule 4 −1.7 5.1 2.4 6.5 
HAS1 Hyaluronan synthase 1 2.1 9.6 4.1 6.5 
CCL5 Chemokine (RANTES) −1.0 6.9 2.9 6.4 
GPR43 GPCR 43 (FFAR2) −1.3 4.8 1.7 6.1 
PMAIP1 PMA-induced protein 1; Bcl-2 family (NOXA) 2.9 16.1 11.3 6.0 
SGPP2 Sphingosine-1-phosphate phosphatase 2 1.3 9.0 4.2 5.9 
CCRN4L CCR4 carbon catabolite repression 4-like (Saccharomyces cerevisiae) 1.4 7.3 4.4 5.9 
TPD52 Tumor protein D52 3.0 8.7 14.6 5.9 
PLEKHF2 Pleckstrin homology domain containing, F2 −1.3 4.8 2.0 5.6 
SYNPO2 Synaptopodin 2 −1.1 6.7 3.1 5.4 
CASP5 Caspase 5; apoptosis-related cysteine protease −1.3 4.8 1.8 5.4 
MAP3K8 MEK kinase 8 (TPL2) 1.3 8.0 3.4 5.4 
HS3ST3B1 Heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 −1.3 4.3 2.0 5.3 
IL10 IL 10 1.5 12.1 7.2 5.3 
EZH2 Enhancer of zeste (polycomb group) homolog −1.7 4.2 1.6 5.2 
MAP3K4 MEK kinase 4 1.5 8.9 6.1 5.2 
IL1A Interleukin 1, α 2.1 10.3 9.6 5.1 
GJB2 Gap junction protein, β2, 26kDa (connexin 26) 2.9 14.0 12.7 5.1 
BIRC3 Baculoviral IAP repeat-containing 3 (CIAP2) −1.3 4.2 2.2 5.1 
TRGV9c TCR γ alternate reading frame protein −1.0 6.2 1.8 4.8 
SLAMF1 Signaling lymphocytic activation molecule family, 1 1.2 5.7 6.3 4.7 
PLA1A Phospholipase A1, A 1.6 8.5 4.7 4.7 
GADD45A Growth arrest and DNA-damage-inducible, α 2.0 8.8 8.1 4.7 
IL2RA IL 2 receptor, α 1.3 5.9 3.1 4.3 
IL18 IL 18 1.9 7.6 4.9 4.2 
RIPK2 Receptor-interacting serine-threonine kinase 2 1.1 4.9 3.2 4.0 
ADAMDEC1 ADAM-like, decysin 1 (disintegrin metalloproteinase) 1.2 5.4 3.2 4.0 
TBK1 TANK-binding kinase 1 1.2 4.9 4.1 4.0 
RHOH Ras homolog gene family, H 1.1 4.5 2.2 3.9 
IL7R Interleukin 7 receptor 1.2 5.2 2.7 3.9 
PTX3 Pentaxin-related gene, induced by IL-1β (TNFAIP5) 1.8 7.0 5.4 3.8 
CLC Cardiotrophin-like cytokine (lysophospholipase) 1.1 4.2 4.2 3.8 
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 1.4 5.5 4.2 3.8 
ARL8 ADP-ribosylation factor-like 8 (Ras superfamily) 2.4 8.2 8.0 3.7 
GBP1 Guanylate binding protein 1, interferon-inducible, 67 kDa 1.5 5.0 3.3 3.6 
NDP Norrie disease (pseudoglioma) 1.5 9.2 2.7 3.6 
TRAF1 TNF receptor-associated factor 1 1.1 4.1 3.2 3.6 
SAV1 Salvador homolog (WW domain containing) 1.5 6.4 4.7 3.5 
XTP2 HbxAg transactivated protein 2 (BAT2D1) 1.2 4.3 4.2 3.4 
SOCS3 Suppressor of cytokine signaling 3 1.3 4.3 2.8 3.4 
G0S2 Putative lymphocyte G0/G1 switch gene 2.1 6.1 5.4 3.4 
TWISTNB TWIST neighbor 1.4 4.9 2.8 3.3 
SPG3A Spastic paraplegia 3A GTPase; vesicle trafficking 2.5 11.0 8.1 3.3 
CFLAR CASP8 and FADD-like apoptosis regulator 1.4 4.7 4.0 3.3 
DUSP2 Dual specificity phosphatase 2 2.7 5.7 5.7 3.1 
TEX14 Testis expressed sequence 14 3.2 13.4 15.2 3.1 
SIAH2 Seven in absentia homolog; ubiquitin ligase 2.1 7.0 4.2 3.0 
  (Table continues)    
GeneDescriptionFold InductionRatiob
TREMLPSDual
IL23A IL 23, α subunit (IL-23p19) 1.1 54.4 18.4 76.4 
TNIP3 TNFAIP3 interacting protein 3 (ABIN-3) 1.2 124.2 14.3 64.7 
CSF3 Colony stimulating factor 3 (G-CSF) 1.3 45.2 36.4 54.4 
IL12B IL 12, β subunit (IL-12p40) −1.1 31.8 4.0 31.1 
EBI3 EBV induced gene 3 (IL-27, β subunit) −1.9 10.5 2.8 20.9 
CCL23 Chemokine (MIP-3) −2.0 5.6 1.5 16.8 
PTTG1IP Pituitary tumor-transforming 1 interacting protein −1.6 8.0 2.9 15.2 
TIFA TRAF-interacting with a Forkhead-associated domain −2.3 6.7 2.7 14.8 
IL1F9 IL 1 family, 9 (ε) 2.7 34.3 23.5 13.9 
KCNJ2 K+ inwardly-rectifying channel, J2 −2.3 5.7 1.6 13.0 
BF B-factor; complement factor B (CFB) 1.2 13.0 4.7 12.6 
GBP3 Guanylate binding protein 3 −2.2 4.9 2.3 10.7 
CIAS1 Cold autoinflammatory syndrome 1 (NLRP3/cryopyrin) −1.2 7.6 5.1 9.8 
CDC2 Cell division cycle 2, G1 to S and G2 to M 1.6 12.8 6.5 9.4 
TPRT Trans-Prenyltransferase (PDSS1) −1.0 9.5 5.7 9.2 
CXCL1 Chemokine (GRO-α) 2.6 21.7 9.2 9.1 
TSLP Thymic stromal lymphopoietin (cytokine) 3.6 30.8 37.6 9.1 
NFKBIZ NF-κB gene enhancer in B-cells inhibitor, ζ −1.8 4.4 3.4 8.2 
PDCD1LG1 Programmed cell death 1 ligand 1 (B7-H1) 2.0 17.6 6.6 7.7 
ZBTB10 Zn2+ finger and BTB domain containing 10 −1.1 6.4 4.1 7.6 
LAMP3 Lysosomal-associated membrane protein 3 (DC-LAMP) 1.1 10.5 3.8 7.2 
MCOLN2 Mucolipin 2; cation channel −1.3 5.1 2.0 7.2 
IL15RA IL 15 receptor, α −1.4 4.2 2.2 6.6 
ICAM4 Intercellular adhesion molecule 4 −1.7 5.1 2.4 6.5 
HAS1 Hyaluronan synthase 1 2.1 9.6 4.1 6.5 
CCL5 Chemokine (RANTES) −1.0 6.9 2.9 6.4 
GPR43 GPCR 43 (FFAR2) −1.3 4.8 1.7 6.1 
PMAIP1 PMA-induced protein 1; Bcl-2 family (NOXA) 2.9 16.1 11.3 6.0 
SGPP2 Sphingosine-1-phosphate phosphatase 2 1.3 9.0 4.2 5.9 
CCRN4L CCR4 carbon catabolite repression 4-like (Saccharomyces cerevisiae) 1.4 7.3 4.4 5.9 
TPD52 Tumor protein D52 3.0 8.7 14.6 5.9 
PLEKHF2 Pleckstrin homology domain containing, F2 −1.3 4.8 2.0 5.6 
SYNPO2 Synaptopodin 2 −1.1 6.7 3.1 5.4 
CASP5 Caspase 5; apoptosis-related cysteine protease −1.3 4.8 1.8 5.4 
MAP3K8 MEK kinase 8 (TPL2) 1.3 8.0 3.4 5.4 
HS3ST3B1 Heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 −1.3 4.3 2.0 5.3 
IL10 IL 10 1.5 12.1 7.2 5.3 
EZH2 Enhancer of zeste (polycomb group) homolog −1.7 4.2 1.6 5.2 
MAP3K4 MEK kinase 4 1.5 8.9 6.1 5.2 
IL1A Interleukin 1, α 2.1 10.3 9.6 5.1 
GJB2 Gap junction protein, β2, 26kDa (connexin 26) 2.9 14.0 12.7 5.1 
BIRC3 Baculoviral IAP repeat-containing 3 (CIAP2) −1.3 4.2 2.2 5.1 
TRGV9c TCR γ alternate reading frame protein −1.0 6.2 1.8 4.8 
SLAMF1 Signaling lymphocytic activation molecule family, 1 1.2 5.7 6.3 4.7 
PLA1A Phospholipase A1, A 1.6 8.5 4.7 4.7 
GADD45A Growth arrest and DNA-damage-inducible, α 2.0 8.8 8.1 4.7 
IL2RA IL 2 receptor, α 1.3 5.9 3.1 4.3 
IL18 IL 18 1.9 7.6 4.9 4.2 
RIPK2 Receptor-interacting serine-threonine kinase 2 1.1 4.9 3.2 4.0 
ADAMDEC1 ADAM-like, decysin 1 (disintegrin metalloproteinase) 1.2 5.4 3.2 4.0 
TBK1 TANK-binding kinase 1 1.2 4.9 4.1 4.0 
RHOH Ras homolog gene family, H 1.1 4.5 2.2 3.9 
IL7R Interleukin 7 receptor 1.2 5.2 2.7 3.9 
PTX3 Pentaxin-related gene, induced by IL-1β (TNFAIP5) 1.8 7.0 5.4 3.8 
CLC Cardiotrophin-like cytokine (lysophospholipase) 1.1 4.2 4.2 3.8 
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 1.4 5.5 4.2 3.8 
ARL8 ADP-ribosylation factor-like 8 (Ras superfamily) 2.4 8.2 8.0 3.7 
GBP1 Guanylate binding protein 1, interferon-inducible, 67 kDa 1.5 5.0 3.3 3.6 
NDP Norrie disease (pseudoglioma) 1.5 9.2 2.7 3.6 
TRAF1 TNF receptor-associated factor 1 1.1 4.1 3.2 3.6 
SAV1 Salvador homolog (WW domain containing) 1.5 6.4 4.7 3.5 
XTP2 HbxAg transactivated protein 2 (BAT2D1) 1.2 4.3 4.2 3.4 
SOCS3 Suppressor of cytokine signaling 3 1.3 4.3 2.8 3.4 
G0S2 Putative lymphocyte G0/G1 switch gene 2.1 6.1 5.4 3.4 
TWISTNB TWIST neighbor 1.4 4.9 2.8 3.3 
SPG3A Spastic paraplegia 3A GTPase; vesicle trafficking 2.5 11.0 8.1 3.3 
CFLAR CASP8 and FADD-like apoptosis regulator 1.4 4.7 4.0 3.3 
DUSP2 Dual specificity phosphatase 2 2.7 5.7 5.7 3.1 
TEX14 Testis expressed sequence 14 3.2 13.4 15.2 3.1 
SIAH2 Seven in absentia homolog; ubiquitin ligase 2.1 7.0 4.2 3.0 
  (Table continues)    
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