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Table III.

Spinal cord 1,25-(OH)2D3 in SHAM and OVX mice with placebo or E2 implants and fed 0 or 1 μg/day vitamin D3

SurgeryaVitamin D3 (μg/day)E2 Implant (mg)Spinal Cord 1,25-(OH)2D3b (fmol/g)
SHAM 44 ± 24 
SHAM 226 ± 293 
OVX 59 ± 22 
OVX 189 ± 64** 
OVX 0.1 29 ± 5 
OVX 0.1 178 ± 92** 
SurgeryaVitamin D3 (μg/day)E2 Implant (mg)Spinal Cord 1,25-(OH)2D3b (fmol/g)
SHAM 44 ± 24 
SHAM 226 ± 293 
OVX 59 ± 22 
OVX 189 ± 64** 
OVX 0.1 29 ± 5 
OVX 0.1 178 ± 92** 
a

Female B6 mice were fed diets with 0 or 1 μg/day vitamin D3 continuously beginning 1 wk before surgery. OVX or SHAM surgery was performed and a placebo or E2 pellet (0.1 mg; 60-day release) was implanted s.c. in each OVX mouse. Two weeks after surgery the mice were immunized with MOG35–55 peptide.

b

Spinal cord 1,25-(OH)2D3 were quantified at the end of the study. The data shown are the means ± SD (≥6–7 mice/group) from one experiment of three. **, p < 0.005 for comparisons between −D and +D mice within the same surgical and implant groups (Mann-Whitney test).

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