American Association of Immunologists

Table I.

Enzyme potency of INCB028050 (nM ± SD)

JAK1	JAK2	JAK3	Tyk2	cMET	Chk2
5.9 ± 0.9 n = 4	5.7 ± 1.7 n = 6	>400 n = 2	53 n = 2	>10,000^a n = 1	>1,000^a n = 1

JAK1	JAK2	JAK3	Tyk2	cMET	Chk2
5.9 ± 0.9 n = 4	5.7 ± 1.7 n = 6	>400 n = 2	53 n = 2	>10,000^a n = 1	>1,000^a n = 1

^a

Highest concentration tested.