American Association of Immunologists

Table III.

Sustained modest inhibition of JAK1/2 is efficacious in the rAIA model (n = 6, ± SD)

Dose (mg/kg/d)^a	INCB028050 Plasma Concentration (nM)	pSTAT3 (% Inhibition)^b	Clinical Score (% Inhibition)	Paw Swelling (% Inhibition)	Histologic Improvement (%)
0.18	13 ± 2	14	25 ± 42	63 ± 15	29 ± 15
0.6	53 ± 8	36	50 ± 34	96 ± 36	40 ± 8
1.8	181 ± 19	62	90 ± 18	≥100	60 ± 10

Dose (mg/kg/d)^a	INCB028050 Plasma Concentration (nM)	pSTAT3 (% Inhibition)^b	Clinical Score (% Inhibition)	Paw Swelling (% Inhibition)	Histologic Improvement (%)
0.18	13 ± 2	14	25 ± 42	63 ± 15	29 ± 15
0.6	53 ± 8	36	50 ± 34	96 ± 36	40 ± 8
1.8	181 ± 19	62	90 ± 18	≥100	60 ± 10

Based on a body weight of 200 g.

Extrapolated from Fig. 1D.