Vessel diameter in rats before (basal) and at different time points (15–60 min) after the addition of the PAR2-APs (SL-NH2 and Tc-NH2) or control peptides (LR-NH2 and LS-NH2)a
| Time (min) . | Vessel Diameter (μm) . | . | . | . | |||
|---|---|---|---|---|---|---|---|
| . | LR-NH2 (control) . | LS-NH2 (control) . | SL-NH2 (PAR2-AP) . | Tc-NH2 (PAR2-AP) . | |||
| Basal | 29.1 ± 2.9 | 31.2 ± 1.1 | 33.3 ± 2.1 | 29.0 ± 2.3 | |||
| 15 | 29.7 ± 2.9 | 32.4 ± 0.8 | 33.0 ± 1.7 | 25.5 ± 2.8 | |||
| 30 | 29.7 ± 2.9 | 33.5 ± 1.3 | 33.7 ± 2.4 | 27.3 ± 2.4 | |||
| 45 | 29.5 ± 3.0 | 33.3 ± 1.5 | 33.4 ± 2.3 | 27.8 ± 2.1 | |||
| 60 | 29.6 ± 2.6 | 32.2 ± 1.6 | 33.3 ± 2.4 | 28.8 ± 2.6 | |||
| Time (min) . | Vessel Diameter (μm) . | . | . | . | |||
|---|---|---|---|---|---|---|---|
| . | LR-NH2 (control) . | LS-NH2 (control) . | SL-NH2 (PAR2-AP) . | Tc-NH2 (PAR2-AP) . | |||
| Basal | 29.1 ± 2.9 | 31.2 ± 1.1 | 33.3 ± 2.1 | 29.0 ± 2.3 | |||
| 15 | 29.7 ± 2.9 | 32.4 ± 0.8 | 33.0 ± 1.7 | 25.5 ± 2.8 | |||
| 30 | 29.7 ± 2.9 | 33.5 ± 1.3 | 33.7 ± 2.4 | 27.3 ± 2.4 | |||
| 45 | 29.5 ± 3.0 | 33.3 ± 1.5 | 33.4 ± 2.3 | 27.8 ± 2.1 | |||
| 60 | 29.6 ± 2.6 | 32.2 ± 1.6 | 33.3 ± 2.4 | 28.8 ± 2.6 | |||
The tested peptides were superfused on the postcapillary mesenteric venules for 1 min. starting immediately after the basal period. Values are mean ± SEM of n = 6 per group.